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2-Chloro-5-methoxypyrimidine

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Products Intro: Product Name:2-Chloro-5-methoxypyrimidine
CAS:22536-65-8
Purity:98%(Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg
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CAS:22536-65-8
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CAS:22536-65-8
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CAS:22536-65-8
Purity:>97% Package:1g;5g;10g;25g;100g

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2-Chloro-5-methoxypyrimidine Basic information
Product Name:2-Chloro-5-methoxypyrimidine
Synonyms:Pyrimidine, 2-chloro-5-methoxy- (8CI,9CI);2-Chloro-5-methoxypyrimidine;PyriMidine,2-chloro-5-Methoxy-;2-Chloro-5-MethoxypyriMidine 97%;2-Chloro-5-methoxypyrimidine >;2-Chloro-5-methoxypyrimidine ISO 9001：2015 REACH;2-Chloro-5-methoxypyrimidine, 97%,;2-CHLORO-5-(METHOXY-D3)PYRIMIDINE
CAS:22536-65-8
MF:C5H5ClN2O
MW:144.56
EINECS:636-584-4
Product Categories:Heterocycle-Pyrimidine series;Building Blocks;C4 to C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;PYRIMIDINE
Mol File:22536-65-8.mol
2-Chloro-5-methoxypyrimidine Structure
2-Chloro-5-methoxypyrimidine Chemical Properties
Melting point 73-78℃
Boiling point 268.8±13.0 °C(Predicted)
density 1.292±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
form powder to crystal
pka-1.26±0.22(Predicted)
color White to Almost white
InChIInChI=1S/C5H5ClN2O/c1-9-4-2-7-5(6)8-3-4/h2-3H,1H3
InChIKeyRSUBGBZOMBTDTI-UHFFFAOYSA-N
SMILESC1(Cl)=NC=C(OC)C=N1
CAS DataBase Reference22536-65-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 37/38-41
Safety Statements 26-39
WGK Germany 3
HS Code 29335990
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
MSDS Information
2-Chloro-5-methoxypyrimidine Usage And Synthesis
Chemical Propertiesoff-white powder
Uses2-Chloro-5-methoxypyrimidine is used in the regioselective synthesis of aminoimidazopyrimidines with triflic anhydride and pyridine bases
Synthesis
2,4-Dichloro-5-methoxypyrimidine

19646-07-2

2-Chloro-5-methoxypyrimidine

22536-65-8

General procedure for the synthesis of 2-chloro-5-methoxypyrimidine from 2,4-dichloro-5-methoxypyrimidine: 1. 2,4-Dichloro-5-methoxypyrimidine (43 g, 0.24 mol), zinc powder (86 g, 1.32 mol), ethanol (200 mL), and water (200 mL) were mixed, heated to reflux, and the reaction was maintained for 4 hours. 2. After completion of the reaction, the reaction mixture was filtered while hot. 3. The filtrate was distilled under reduced pressure to remove ethanol. 4. 4. After cooling, the product was extracted with ether. 5. 5. The extract was recrystallized from light petroleum ether (boiling point: 40-60 °C) to give purified 2-chloro-5-methoxypyrimidine (20 g, 58% yield).

References[1] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 24
[2] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 27
2-Chloro-5-methoxypyrimidine Preparation Products And Raw materials
Raw materials2,4-Dichloro-5-methoxypyrimidine-->Ethanol-->ZINC-->Water
Preparation Productsmethyl 5-methoxypyrimidine-2-carboxylate-->2-Chloro-5-hydroxypyrimidine
Tag:2-Chloro-5-methoxypyrimidine(22536-65-8) Related Product Information
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