Histamine dihydrochloride r(-)-α-methyl

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Histamine dihydrochloride r(-)-α-methyl Basic information
Product Name:Histamine dihydrochloride r(-)-α-methyl
Synonyms:R-(-)-2-(1H-Imidazol-4-yl)-1-methyl-ethylamine dihydrochloride;(R)-1-(1H-Imidazol-4-yl)propan-2-amine dihydrochloride;R-()-α-Methylhistamine (hydrochloride);R-(?)-α-Methylhistamine hydrochloride;R(-)-α-Methyl Histamine Dihydrochloride;(R)()-α-Methylhistamine;(R)()αMethylhistamine dihydrochloride,(R) ( ) α Methylhistamine dihydrochloride;(R)-2-(1H-Imidazol-4-yl)-1-methyl-ethylamine hydrochloride
CAS:75614-89-0
MF:C6H12ClN3
MW:161.63
EINECS:
Product Categories:Pharmaceuticals;Neurochemicals;Intermediates & Fine Chemicals;Heterocycles;Amines
Mol File:75614-89-0.mol
Histamine dihydrochloride r(-)-α-methyl Structure
Histamine dihydrochloride r(-)-α-methyl Chemical Properties
Melting point 169-173°C
storage temp. desiccated
solubility H2O: soluble
form Powder
color white to off-white
Optical Rotation[α]22/D 4°, c = 0.8 in H2O(lit.)
Water Solubility H2O: soluble
Sensitive Hygroscopic
InChI1S/C6H11N3.2ClH/c1-5(7)2-6-3-8-4-9-6;;/h3-5H,2,7H2,1H3,(H,8,9);2*1H/t5-;;/m1../s1
InChIKeyIZHCNQFUWDFPCW-ZJIMSODOSA-N
SMILESCl.Cl.C[C@@H](N)Cc1c[nH]cn1
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
Histamine dihydrochloride r(-)-α-methyl Usage And Synthesis
UsesPotent, selective H3 histamine receptor agonist which crosses the blood-brain barrier; inhibits histamine synthesis and release.
UsesR(-)-α-Methyl Histamine Dihydrochloride is a potent and selective H3 histamine receptor agonist that inhibits the synthesis and release of histamine (1,2,3,4). R(-)-α-Methyl Histamine Dihydrochloride is a blood-brain barrier penetrant.
Biochem/physiol ActionsPotent, selective H3 histamine receptor agonist which crosses the blood-brain barrier; inhibits histamine synthesis and release.
in vivo

Pretreatment with (R)-(-)-α-Methylhistamine dihydrochloride (RAMH; 10 mg/kg; i.p.; 60 min before training) reverses Propofol‐induced (25 mg/kg; i.p.; 30 min before training) memory retention[5].
(R)-(-)-α-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[3].

Animal Model:Male Sprague‐Dawley rats (10-12 week)[3]
Dosage:10 mg/kg
Administration:IP; 60 min before training
Result:Reversed propofol‐induced memory retention.
IC 50H3 receptor: 50.3 nM (Kd)
Histamine dihydrochloride r(-)-α-methyl Preparation Products And Raw materials
Tag:Histamine dihydrochloride r(-)-α-methyl(75614-89-0) Related Product Information
Histamine dihydrochloride L-(-)-Histidinol dihydrochloride (R)-(-)-alpha-Methylhistamine dihydrobromide (S)-(+)-alpha-Methyl-1H-imidazole-4-ethanamine dihydrobromide α-Methylhistamine dihydrochloride 2-(1H-Imidazol-4-yl)-1-methyl-ethylamine 2HCl