1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo-

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1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- manufacturers

  • WRX606
  • WRX606 pictures
  • 2026-08-27
  • CAS:899937-47-4
  • Min. Order: 1KG
  • Purity: 98
  • Supply Ability: 1000 KG
1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- Basic information
Product Name:1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo-
Synonyms:1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo-;N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(1-(2-((3-chlorophenyl)amino)-2-oxoethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)butanamide;N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-[1-[2-[(3-chlorophenyl)amino]-2-oxoethyl]-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl]butanamide;3-[4-[(1,3-Benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo-1(2H)-quinazolineacetamide;(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo-
CAS:899937-47-4
MF:C28H25ClN4O6
MW:548.97
EINECS:
Product Categories:
Mol File:899937-47-4.mol
1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- Structure
1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- Chemical Properties
density 1.419±0.06 g/cm3(Predicted)
form Solid
pka13.25±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- Usage And Synthesis
UsesWRX606 is an inhibitor for mTOR complex 1 (mTORC1). WRX606 inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 S6K1 (IC50=10 nM), and the phosphorylation of the eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) (IC50=0.27 μM) in MCF-7. WRX606 exhibits cytotoxicity to HepG2 with IC50 of 17 nM. WRX606 exhibits antitumor efficacy in mouse models[1].
References[1] Shams R, et al., In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC1. J Med Chem. 2022 Jan 27;65(2):1329-1341. DOI:10.1021/acs.jmedchem.1c00536
1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo- Preparation Products And Raw materials
Tag:1(2H)-Quinazolineacetamide, 3-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutyl]-N-(3-chlorophenyl)-3,4-dihydro-2,4-dioxo-(899937-47-4) Related Product Information
2,4(1H,3H)-Quinazolinedione, 7-chloro-3-(3,4-dimethoxyphenyl)- 3-(3-Chlorophenyl)-6,7-dimethoxyquinazoline-2,4(1H,3H)-dione 2,4(1H,3H)-Quinazolinedione, 7-chloro-3-(4-methoxyphenyl)- Benzamide, 2-[[2-[(1,3-benzodioxol-5-ylmethyl)amino]-2-oxoethyl]amino]-5-chloro- 2,4(1H,3H)-Quinazolinedione, 7-chloro-3-(4-ethoxyphenyl)- WRX606