Pentanamide, 2-amino-N-[3-(difluoromethoxy)-4-(5-oxazolyl)phenyl]-4-methyl-, (2R)- manufacturers
- BMS-911172
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- $828.00
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2026-07-16
- CAS:1644248-18-9
- Purity: 99.87%
- Supply Ability: 10g
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| | Pentanamide, 2-amino-N-[3-(difluoromethoxy)-4-(5-oxazolyl)phenyl]-4-methyl-, (2R)- Basic information |
| | Pentanamide, 2-amino-N-[3-(difluoromethoxy)-4-(5-oxazolyl)phenyl]-4-methyl-, (2R)- Chemical Properties |
| Boiling point | 474.3±45.0 °C(Predicted) | | density | 1.258±0.06 g/cm3(Predicted) | | pka | 13.03±0.70(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | Pentanamide, 2-amino-N-[3-(difluoromethoxy)-4-(5-oxazolyl)phenyl]-4-methyl-, (2R)- Usage And Synthesis |
| Description | BMS-911172 is a potent and brain-penetrant, AP2-associated protein kinase 1 (AAK1)-selective inhibitor (IC50 = 12 and 51 nM in enzymes and cells, respectively). BMS-911172 was active in the formalin assay in the Chung mouse model (60 mg/kg s.c.) as well as in the chronic constriction injury-induced thermal hyperalgesia and mechanical allodynia rat model (60 mg/kg). PD marker assay in mice showed a dose-dependent inhibition of phosphorylation of AAK1 substrate mu-2 in the brain. There were no motor side effects at the doses tested. BMS-911172 may be useful for the treatment of neuropathic pain | | Uses | BMS-911172 is an adaptor associated kinase 1 (AAK1 kinase) inhibitor (IC50 = 35 nM). | | References | [1] Hartz RA, et al. Aryl amide kinase inhibitors. WO2015006100A1. |
| | Pentanamide, 2-amino-N-[3-(difluoromethoxy)-4-(5-oxazolyl)phenyl]-4-methyl-, (2R)- Preparation Products And Raw materials |
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