| Company Name: |
InvivoChem |
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+1-708-310-1919 +1-13798911105 |
| Email: |
sales@invivochem.cn |
| Company Name: |
InvivoChem |
| Tel: |
13549236410 |
| Email: |
sales@invivochem.cn |
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| | L-Leucine-13C6 Basic information |
| Product Name: | L-Leucine-13C6 | | Synonyms: | L-Leucine-13C?;13C6]-L-Leucine;L-Leucine-1,2,3,4,5,5′-13C6;L-Leucine-13C6;L-Leucine (13C?, 99%);L-Leucine-13 C 6 (Standard) | | CAS: | 201740-84-3 | | MF: | C6H13NO2 | | MW: | 137.13 | | EINECS: | | | Product Categories: | | | Mol File: | 201740-84-3.mol |  |
| | L-Leucine-13C6 Chemical Properties |
| Melting point | >300°C (lit.) | | density | 1.036±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | form | Solid | | color | White to off-white | | Optical Rotation | [α]25/D +14.5°, c =2 in 5 M HCl | | InChI | 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1 | | InChIKey | ROHFNLRQFUQHCH-IQUPZBQQSA-N | | SMILES | [13CH3][13CH]([13CH3])[13CH2][13C@H](N)[13C](O)=O | | CAS Number Unlabeled | 61-90-5 |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | L-Leucine-13C6 Usage And Synthesis |
| Description | L-LEUCINE-13C6, also known as 13C6-D-Leucine or L-Leucine-1,2,3,4,5,5'-13C6, is a fully 13C labelled D-Leucine. | | Uses | Leucine-13C6 is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. DOI:10.1371/journal.pgen.1003857
[3] Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. DOI:10.1186/1743-7075-9-77
[4] Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. DOI:10.2337/db11-0765 |
| | L-Leucine-13C6 Preparation Products And Raw materials |
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