3,6,9-Trioxa-12,15-diazahexadecanamide, 15-[4-(4-acetylhexahydro-1H-1,4-diazepin-1-yl)-6-[[2-(2-thienyl)ethyl]amino]-1,3,5-triazin-2-yl]-N-[(1S)-1-[[(2R,4S)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dime

Request For Quotation
3,6,9-Trioxa-12,15-diazahexadecanamide, 15-[4-(4-acetylhexahydro-1H-1,4-diazepin-1-yl)-6-[[2-(2-thienyl)ethyl]amino]-1,3,5-triazin-2-yl]-N-[(1S)-1-[[(2R,4S)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]-13-oxo- Suppliers list
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: Shanghai Amole Biotechnology Co., Ltd.  
Tel: 13370042665 18916960931
Email: 2596183085@qq.com

3,6,9-Trioxa-12,15-diazahexadecanamide, 15-[4-(4-acetylhexahydro-1H-1,4-diazepin-1-yl)-6-[[2-(2-thienyl)ethyl]amino]-1,3,5-triazin-2-yl]-N-[(1S)-1-[[(2R,4S)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]-13-oxo- manufacturers

  • C004019
  • C004019 pictures
  • $263.00
  • 2026-08-20
  • CAS:2417159-57-8
  • Purity: 99.89%
  • Supply Ability: 10g
3,6,9-Trioxa-12,15-diazahexadecanamide, 15-[4-(4-acetylhexahydro-1H-1,4-diazepin-1-yl)-6-[[2-(2-thienyl)ethyl]amino]-1,3,5-triazin-2-yl]-N-[(1S)-1-[[(2R,4S)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]-13-oxo- Basic information
Product Name:3,6,9-Trioxa-12,15-diazahexadecanamide, 15-[4-(4-acetylhexahydro-1H-1,4-diazepin-1-yl)-6-[[2-(2-thienyl)ethyl]amino]-1,3,5-triazin-2-yl]-N-[(1S)-1-[[(2R,4S)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]-13-oxo-
Synonyms:3,6,9-Trioxa-12,15-diazahexadecanamide, 15-[4-(4-acetylhexahydro-1H-1,4-diazepin-1-yl)-6-[[2-(2-thienyl)ethyl]amino]-1,3,5-triazin-2-yl]-N-[(1S)-1-[[(2R,4S)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]-13-oxo-;C004019
CAS:2417159-57-8
MF:C49H70N12O9S2
MW:1035.29
EINECS:
Product Categories:
Mol File:2417159-57-8.mol
3,6,9-Trioxa-12,15-diazahexadecanamide, 15-[4-(4-acetylhexahydro-1H-1,4-diazepin-1-yl)-6-[[2-(2-thienyl)ethyl]amino]-1,3,5-triazin-2-yl]-N-[(1S)-1-[[(2R,4S)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]-13-oxo- Structure
3,6,9-Trioxa-12,15-diazahexadecanamide, 15-[4-(4-acetylhexahydro-1H-1,4-diazepin-1-yl)-6-[[2-(2-thienyl)ethyl]amino]-1,3,5-triazin-2-yl]-N-[(1S)-1-[[(2R,4S)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]-13-oxo- Chemical Properties
density 1.300±0.06 g/cm3(Predicted)
pka13.54±0.46(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
3,6,9-Trioxa-12,15-diazahexadecanamide, 15-[4-(4-acetylhexahydro-1H-1,4-diazepin-1-yl)-6-[[2-(2-thienyl)ethyl]amino]-1,3,5-triazin-2-yl]-N-[(1S)-1-[[(2R,4S)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]-13-oxo- Usage And Synthesis
UsesC004019 is a BBB-penatrable and small-molecule PROTAC that targets tau. C004019 can simultaneously recruit tau and E3 ligase, and effectively clear tau proteins by promoting the ubiquitination and proteasome-dependent degradation of tau, thereby improving synaptic and cognitive functions in Alzheimer's disease (AD) mice. C004019 can be used in the research of AD and tau protein-related diseases. (Pink: Ligand for target protein (HY-138679); Black: linker (HY-140189); Blue: E3 Ligase Ligand (HY-138678))[1]
in vivo

C004019 (intracerebroventricular injection; 5 μL; 200 μM; single dose) reduces the level of tau protein in the brains of wild-type and 3xTg-AD mice[1].
C004019 (subcutaneous injection; 3-15 mg/kg; single dose) effectively clears tau protein in the brains of wild-type mice[1].
C004019 (subcutaneous injection; 3 mg/kg; once every 6 days for five times) promotes tau clearance and improves cognitive and synaptic functions in hTau and 3xTg-AD mice[1].

Animal Model:hTau transgenic mice aged 12 months old[1]
Dosage:3 mg/kg
Administration:Subcutaneous injection (s.c.); once every 6 days for a total of 5 times
Result:Significantly reduced total and p-tau levels in the hippocampal extracts.
Reduced both soluble and insoluble tau, more efficiently to the tau in the soluble fraction.
Ameliorated cognitive functions and dentritic plasticity in hTau transgenic mouse model.
Animal Model:3xTg-AD mice aged 9.5 months old[1]
Dosage:3 mg/kg
Administration:Subcutaneous injection (s.c.); once every 6 days for a total of 5 times
Result:Remarkably reduced both soluble and insoluble tau levels in hippocampal and cortex extracts, more efficiently to the tau in the soluble fraction.
Significantly reduced T22-positive tau in the soluble fraction.
Improved the cognitive and synaptic functions in 3xTg-AD mice.
References[1] Wang W, et al. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021 Mar 11;11(11):5279-5295. DOI:10.7150/thno.55680
3,6,9-Trioxa-12,15-diazahexadecanamide, 15-[4-(4-acetylhexahydro-1H-1,4-diazepin-1-yl)-6-[[2-(2-thienyl)ethyl]amino]-1,3,5-triazin-2-yl]-N-[(1S)-1-[[(2R,4S)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]-13-oxo- Preparation Products And Raw materials
Tag:3,6,9-Trioxa-12,15-diazahexadecanamide, 15-[4-(4-acetylhexahydro-1H-1,4-diazepin-1-yl)-6-[[2-(2-thienyl)ethyl]amino]-1,3,5-triazin-2-yl]-N-[(1S)-1-[[(2R,4S)-4-hydroxy-2-[[[[4-(4-methyl-5-thiazolyl)phenyl]methyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]-2,2-dimethylpropyl]-13-oxo-(2417159-57-8) Related Product Information
DT2216 Acetamide, N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- AU-15330 ARV-825 ARV-771 dBET1