ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >protein tyrosine kinase >PELITINIB

PELITINIB

Request For Quotation
PELITINIB Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-（0）57185586718; +8613336195806
Email: sales@capot.com
Products Intro: Product Name:Pelitinib
CAS:257933-82-7
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:257933-82-7 PELITINIB
CAS:257933-82-7
Purity:99% Package:25KG;5KG;1KG
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Pelitinib
CAS:257933-82-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Products Intro: Product Name:PELITINIB
CAS:257933-82-7
Purity:99% Package:1KG;7USD
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:Pelitinib
CAS:257933-82-7
Purity:98% HPLC LCMS Package:10G;20G

PELITINIB manufacturers

  • Pelitinib
  • Pelitinib pictures
  • $15.00 / 1KG
  • 2021-07-13
  • CAS:257933-82-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Pelitinib
  • Pelitinib pictures
  • $15.00 / 1KG
  • 2021-07-10
  • CAS:257933-82-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • PELITINIB
  • PELITINIB pictures
  • $7.00 / 1KG
  • 2019-07-10
  • CAS:257933-82-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100KG
PELITINIB Basic information
Product Name:PELITINIB
Synonyms:PELITINIB;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;WAY-EKB 569;PELITINIB (EKB-569;WAY-EKB 569);EKB-569; WAY-EKB 569; EKB569; EKB 569;(2E)-N-{4-[(3-chloro-4-fluorophenyl)aMino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(diMethylaMino)but-2-enaMide;(E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
CAS:257933-82-7
MF:C24H23ClFN5O2
MW:467.92
EINECS:803-625-4
Product Categories:Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Tyrosine Kinase Inhibitors;pyridine;All Inhibitors;API;Aromatics;Heterocycles;Isotope Labelled Compounds
Mol File:257933-82-7.mol
PELITINIB Structure
PELITINIB Chemical Properties
Melting point 173-178°C
Boiling point 655.5±55.0 °C(Predicted)
density 1.34
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMSO: soluble5mg/mL, clear (warmed)
pka12.23±0.43(Predicted)
form powder
color white to beige
InChIKeyWVUNYSQLFKLYNI-AATRIKPKSA-N
SMILESFc1c(cc(cc1)Nc2c3c(ncc2C#N)cc(c(c3)NC(=O)\C=C\CN(C)C)OCC)Cl
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
HS Code 2933.59.8000
HazardClass 6.1
PackingGroup III
Storage Class6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard ClassificationsAcute Tox. 3 Oral
MSDS Information
PELITINIB Usage And Synthesis
DescriptionPelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM). It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM). By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).
Chemical PropertiesOff-White Solid
UsesPelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
UsesAn EGFR inhibitor
UsesLabelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.
DefinitionChEBI: Pelitinib is an aminoquinoline, a nitrile, a monocarboxylic acid amide and a member of monochlorobenzenes. It has a role as a protein kinase inhibitor.
targetEGFR
storageStore at -20°C
references[1] torrance cj, jackson pe, montgomery e, kinzler kw, vogelstein b, wissner a, nunes m, frost p, discafani cm. combinatorial chemoprevention of intestinal neoplasia. nat med. 2000 sep;6(9):1024-8.
[2] nunes m, shi c, greenberger lm. phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase b, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, ekb-569, in tumor cells and normal human keratinocytes. mol cancer ther. 2004 jan;3(1):21-7.
PELITINIB Preparation Products And Raw materials
Tag:PELITINIB(257933-82-7) Related Product Information
Peficitinib LOXO-101 Ceritinib (LDK378) Lapatinib Sunitinib Ibrutinib PD168393 PI-103 WZ4002 AST-1306 AZD-9291 Canertinib PELITINIB