| Company Name: |
Bide Pharmatech Ltd.
|
| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:ADAMTS-5-IN-2
CAS:294648-66-1
Purity:99% Package:1mg;5mg;10mg;25mg;50mg Remarks:BD01835790
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:ADAMTS-5-IN-2
CAS:294648-66-1
Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
|
| Company Name: |
Anhui JYHX CO., LTD.
|
| Tel: |
0551-68788198 13295518198 |
| Email: |
wangyanan@ahjyhx.com |
| Products Intro: |
CAS:294648-66-1
Purity:95% 97% 98% HPLC Package:MG;G;10G;100G;500G;1kg;100kg;1000kg
|
Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- manufacturers
- ADAMTS-5-IN-2
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- $1980.00 / 50mg
-
2025-10-27
- CAS:294648-66-1
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Basic information |
| | Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Chemical Properties |
| density | 1.38±0.1 g/cm3(Predicted) | | pka | 0.54±0.20(Predicted) | | form | Solid | | color | Light yellow to brown |
| | Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Usage And Synthesis |
| Uses | ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 μM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis[1][2]. | | References | [1] Bompiani KM, et al. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. ACS Comb Sci. 2016 Aug 8;18(8):461-74. DOI:10.1021/acscombsci.6b00033
[2] Matthew G. Bursavich; et al. 5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 2007, 17(20), 5630-5633. |
| | Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Preparation Products And Raw materials |
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