Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl-

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Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Suppliers list
Company Name: Bide Pharmatech Ltd.  
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Company Name: TargetMol Chemicals Inc.  
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Company Name: Anhui JYHX CO., LTD.  
Tel: 055167162561 13295518198
Email: wangyanan@ahjyhx.com
Company Name: TargetMol Chemicals Inc.  
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Email: marketing@targetmol.com

Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- manufacturers

  • ADAMTS-5-IN-2
  • ADAMTS-5-IN-2 pictures
  • $1980.00
  • 2026-05-21
  • CAS:294648-66-1
  • Purity:
  • Supply Ability: 10g
Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Basic information
Product Name:Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl-
Synonyms:Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl-;ADAMTS-5-IN-2
CAS:294648-66-1
MF:C17H15N3OS
MW:309.39
EINECS:
Product Categories:
Mol File:294648-66-1.mol
Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Structure
Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Chemical Properties
density 1.38±0.1 g/cm3(Predicted)
pka0.54±0.20(Predicted)
form Solid
color Light yellow to brown
Safety Information
MSDS Information
Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Usage And Synthesis
UsesADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 μM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis[1][2].
References[1] Bompiani KM, et al. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. ACS Comb Sci. 2016 Aug 8;18(8):461-74. DOI:10.1021/acscombsci.6b00033
[2] Matthew G. Bursavich; et al. 5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 2007, 17(20), 5630-5633.
Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- Preparation Products And Raw materials
Tag:Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl-(294648-66-1) Related Product Information
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