2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]-

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2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]- Suppliers list
Company Name: Alfa Chemistry  
Tel: +1-5166625404;
Email: Info@alfa-chemistry.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]- Basic information
Product Name:2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]-
Synonyms:2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]-;EN171
CAS:2191110-79-7
MF:C17H22N2O
MW:270.37
EINECS:
Product Categories:
Mol File:2191110-79-7.mol
2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]- Structure
2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]- Chemical Properties
Boiling point 436.6±24.0 °C(Predicted)
density 1.13±0.1 g/cm3(Predicted)
pka9.06±0.20(Predicted)
Safety Information
MSDS Information
2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]- Usage And Synthesis
UsesEN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol[1].
References[1] Shao Q, et al. Targeted Protein Localization by Covalent 14-3-3 Recruitment. J Am Chem Soc. 2024 Sep 11;146(36):24788-24799. DOI:10.1021/jacs.3c12389
2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]- Preparation Products And Raw materials
Tag:2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]-(2191110-79-7) Related Product Information
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