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| | 1H-Indole-2-carboxamide, N-[4-amino-1-(2-chloroethyl)-2-naphthalenyl]-5,6,7-trimethoxy- Basic information |
| | 1H-Indole-2-carboxamide, N-[4-amino-1-(2-chloroethyl)-2-naphthalenyl]-5,6,7-trimethoxy- Chemical Properties |
| Boiling point | 622.2±55.0 °C(Predicted) | | density | 1.361±0.06 g/cm3(Predicted) | | pka | 14.12±0.43(Predicted) |
| | 1H-Indole-2-carboxamide, N-[4-amino-1-(2-chloroethyl)-2-naphthalenyl]-5,6,7-trimethoxy- Usage And Synthesis |
| Uses | Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI50 of 34 nM in NCI-60 cell line screening[1]. | | Definition | ChEBI: AS-I-145 is an indolecarboxamide obtained by the formal condensation of the carboxy group of 5,6,7-trimethoxyindole-2-carboxylic acid with the 2-amino group of 1-(2-chloroethyl)-2,4-diaminonaphthalene. It has a role as an antineoplastic agent. It is an indolecarboxamide, an aromatic amine, an aromatic ether and an organochlorine compound. | | References | [1] Rayburn E, et al. Preclinical pharmacology of novel indolecarboxamide ML-970, an investigative anticancer agent. Cancer Chemother Pharmacol. 2012;69(6):1423-1431. DOI:10.1007/s00280-012-1851-9 |
| | 1H-Indole-2-carboxamide, N-[4-amino-1-(2-chloroethyl)-2-naphthalenyl]-5,6,7-trimethoxy- Preparation Products And Raw materials |
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