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T&W GROUP
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021-61551611 13296011611 |
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| Products Intro: |
Product Name:1H-Purin-6-amine, 8-methyl- (9CI)
CAS:22387-37-7
Purity:98% Package:按需包装
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| Company Name: |
Cool Pharm, Ltd
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| Tel: |
021-60455363 18019463053 |
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sales@coolpharm.com |
| Products Intro: |
Product Name:8-Methyl-7H-purin-6-amine
CAS:22387-37-7
Purity:98.0% Package:10g;25g;100g;500g;1kg;5kg;10kg
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| | 1H-Purin-6-amine, 8-methyl- (9CI) Basic information |
| | 1H-Purin-6-amine, 8-methyl- (9CI) Chemical Properties |
| Melting point | 335 °C (decomp) | | Boiling point | 248.7±50.0 °C(Predicted) | | density | 1.71±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 9.86±0.20(Predicted) | | Appearance | Brown to dark brown Solid |
| | 1H-Purin-6-amine, 8-methyl- (9CI) Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 8-methyl-7H-purin-6-amine from acetamide and 4,5,6-triamino-pyrimidine sulfate was as follows: step 1: 4,5,6-triamino-pyrimidine sulfate (3.0 g, 13.4 mmol) and acetamide (1.0 g, 16.9 mmol) were added to a 25 mL autoclave and the reaction was heated to 240°C for 6 hours. Upon completion of the reaction, the crude product was boiled in boiling water for 1 h and subsequently filtered through a diatomaceous earth pad. The filtrate was concentrated and purified by high performance liquid chromatography (HPLC) under the following conditions: gradient elution with 0-10% buffer B (buffer A: 0.1% aqueous solution of triethylammonium acetate; buffer B: acetonitrile solution of 0.1% triethylammonium acetate) for 30 min at a flow rate of 10 mL/min. The fraction corresponding to the target product was collected and concentrated in vacuum to afford 225 mg (11% yield ) of 8-methyl-7H-purin-6-amine. | | References | [1] Journal of Medicinal Chemistry, 1990, vol. 33, # 8, p. 2073 - 2080
[2] Patent: WO2003/93290, 2003, A2. Location in patent: Page/Page column 131-132 |
| | 1H-Purin-6-amine, 8-methyl- (9CI) Preparation Products And Raw materials |
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