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| | Ethyl 2-aminopropanoate hydrochloride Basic information |
| | Ethyl 2-aminopropanoate hydrochloride Chemical Properties |
| Melting point | 85-87 °C(lit.) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Methanol (Sparingly), Water | | form | Granular Powder and Granules | | color | White | | Sensitive | Hygroscopic | | BRN | 3654425 | | Major Application | peptide synthesis | | InChI | InChI=1S/C5H11NO2.ClH/c1-3-8-5(7)4(2)6;/h4H,3,6H2,1-2H3;1H | | InChIKey | JCXLZWMDXJFOOI-UHFFFAOYSA-N | | SMILES | C(=O)(C(N)C)OCC.Cl | | CAS DataBase Reference | 617-27-6(CAS DataBase Reference) | | EPA Substance Registry System | Alanine, ethyl ester, hydrochloride (617-27-6) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | TSCA | TSCA listed | | HS Code | 29224999 | | Storage Class | 11 - Combustible Solids |
| | Ethyl 2-aminopropanoate hydrochloride Usage And Synthesis |
| Chemical Properties | White Crystalline Solid | | Uses | Alanine derivative | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | The general procedure for the synthesis of ethyl 2-aminopropionate hydrochloride from ethanol and DL-alanine was as follows: commercially available DL-alanine (5.00 g, 56.12 mmol) was dissolved in 150 mL of anhydrous ethanol, 5 mL of 37% concentrated hydrochloric acid was added, and the mixture was refluxed for 5 hours. After completion of the reaction, the solvent was removed by evaporation and the resulting colorless oily residue was vacuum dried to give the target product in 92% yield. The product was characterized by 1H NMR (CDCl3): δ 1.05 (t, 3H, J=7.07Hz, -OCH2CH3), 1.45 (d, 3H, J=7.25Hz, -CHCH3), 3.48 (q, 2H, J=7.07Hz, -OCH2CH3), and 4.02 ppm (q, 1H, J=7.25Hz, - CHCH3). High-resolution mass spectrometry (HRMS, ESI, 140 eV) analysis showed that the m/z [M+H+] calculated value for C5H12NO2 was 118.0868 and the measured value was 118.0794. | | References | [1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994, # 7, p. 1455 - 1462
[2] Dalton Transactions, 2008, # 13, p. 1689 - 1697
[3] Polyhedron, 2014, vol. 67, p. 520 - 528
[4] Scientia Pharmaceutica, 2001, vol. 69, # 4, p. 329 - 350
[5] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 6, p. 2336 - 2350 |
| | Ethyl 2-aminopropanoate hydrochloride Preparation Products And Raw materials |
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