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| | L-4-Nitrophenylalanine methyl ester hydrochloride Basic information |
| Product Name: | L-4-Nitrophenylalanine methyl ester hydrochloride | | Synonyms: | P-NITRO-PHENYLALANINE-OME HCL;3-(4-Nitrophenyl)-L-alanine methylester hydrochloride;4-Nitro-L-Phenylalanine Methyl Ester HCl;(S)-Methyl-4-Nitro Phenyl Alaninate hydrochloride;4-Nitro-L-Phenylalanine methyl ester monohydrochloride;4-NO2-Phe-oMe.HCL;L-4-Nitrophenylalanine methyl ester hydrochloride;(S)-Methyl 2-aMino-3-(4-nitrophenyl)propanoate hydrochloride | | CAS: | 17193-40-7 | | MF: | C10H13ClN2O4 | | MW: | 260.67 | | EINECS: | | | Product Categories: | Phenylalanine [Phe, F] | | Mol File: | 17193-40-7.mol |  |
| | L-4-Nitrophenylalanine methyl ester hydrochloride Chemical Properties |
| Melting point | 210-214 °C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | powder to crystal | | color | White to Light yellow | | Optical Rotation | 20.9° (c=1.0 g/100ml, ETOH) | | BRN | 5176380 | | CAS DataBase Reference | 17193-40-7(CAS DataBase Reference) |
| Risk Statements | 22-43-36 | | Safety Statements | 22-36/37-24/25 | | RIDADR | 2811 | | WGK Germany | 3 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29225090 |
| | L-4-Nitrophenylalanine methyl ester hydrochloride Usage And Synthesis |
| Chemical Properties | White solid | | Uses | 4-Nitro-L-Phenylalanine Methyl Ester Hydrochloride, is an intermediate in the synthesis of various pharmaceutical compounds. It can be used for the preparation of Matijing-Su derivatives as potent anti-HBV agents. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | Thionyl chloride (1.03 mL, 14.2 mmol) was slowly added dropwise to a suspension of (S)-2-amino-3-(4-nitrophenyl)propionic acid (0.995 g, 4.73 mmol) dissolved in 10 mL of methanol at 0 °C. After the dropwise addition, the reaction system was gradually warmed up to room temperature. Subsequently, the reaction mixture was heated to reflux the reaction overnight. Upon completion of the reaction, the reaction solution was concentrated by distillation under reduced pressure. The crude product was purified by recrystallization using a mixed solvent of methanol/ethyl acetate, and finally 1.012 g of (S)-4-nitrophenylalanine methyl ester hydrochloride was obtained in 95% yield. | | References | [1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 22, p. 3686 - 3700
[2] Journal of Medicinal Chemistry, 1995, vol. 38, # 18, p. 3566 - 3580
[3] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5407 - 5413
[4] Chemistry - A European Journal, 2017, vol. 23, # 24, p. 5824 - 5829
[5] New Journal of Chemistry, 2017, vol. 41, # 23, p. 14723 - 14729 |
| | L-4-Nitrophenylalanine methyl ester hydrochloride Preparation Products And Raw materials |
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