Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)-

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Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)- Suppliers list
Company Name: Shandong Territorial sea Biological Technology Co., LTD  
Tel: 15092083467
Email: tangfenjiushililiang@leadhigh.com.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)- Basic information
Product Name:Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)-
Synonyms:Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)-;EF-4-177
CAS:2891574-93-7
MF:C18H13F5N3O2S.H
MW:431.38
EINECS:
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Mol File:2891574-93-7.mol
Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)- Structure
Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)- Chemical Properties
pka3.21±0.36(Predicted)
Safety Information
MSDS Information
Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)- Usage And Synthesis
UsesEF-4-177 is an orally active and allosteric CDK2 inhibitor with the IC50 of 87 nM. EF-4-177 can disrupt spermatogenesis[1][2].
IC 50CDK2/cyclinE: 87 nM (IC50)
References[1] Faber EB, et al. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J Med Chem. 2023;66(3):1928-1940. DOI:10.1021/acs.jmedchem.2c01731
[2] Huang Y, et al. Targeting cyclin-dependent kinases: From pocket specificity to drug selectivity. Eur J Med Chem. Published online May 29, 2024. DOI:10.1016/j.ejmech.2024.116547
Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)- Preparation Products And Raw materials
Tag:Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)-(2891574-93-7) Related Product Information
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