| Company Name: |
Energy Chemical |
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021-58432009 400-005-6266 |
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marketing@energy-chemical.com |
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| Product Name: | indanol dehydrogenase | | Synonyms: | indanol dehydrogenase;17-beta-hydroxysteroid dehydrogenase type 5;AKR1C3;aldo-keto reductase family 1 member C3;Prostaglandin F Synthase human;AKR1C3 human;DD3;DDX | | CAS: | 55976-95-9 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![indanol dehydrogenase Structure]() |
| | indanol dehydrogenase Chemical Properties |
| storage temp. | -70°C | | form | liquid | | Specific Activity | ≥0.4μmol/mg protein |
| WGK Germany | 1 | | Storage Class | 10 - Combustible liquids |
| | indanol dehydrogenase Usage And Synthesis |
| Uses | Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma . | | Biological Activity | PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways . | | Description | AKR1C3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 323 amino acids (1-323) and having a molecular mass of 36.8 kDa.
AKR1C3 is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | Aldo-keto reductase family 1 member C3 isoform 1 or AKR1C3 is an enzyme, part of the aldo-keto reductase family that promotes conversion of ketones & aldehydes to the alcohol forms while using cofactors such as NADPH & NADH. AKR1C3 promotes the reduction of PG molecule (prostaglandin), PQ (phenanthrenequinone) & PGH2. Another role is oxidation of 9 alpha, 11 beta-PGF2 to PGD2. AKR1C3 holds a crucial part in the pathogenesis of allergic diseases like asthma and can also take part in the regulation of cell growth and differentiation. |
| | indanol dehydrogenase Preparation Products And Raw materials |
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