- Songorine
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- $64.00
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2026-05-11
- CAS:509-24-0
- Purity: 98.97%
- Supply Ability: 10g
- Songorine
-
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2023-02-24
- CAS:509-24-0
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- songorine
-
- $1.00
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2019-12-31
- CAS:509-24-0
- Min. Order: 1KG
- Purity: 95-99%
- Supply Ability: 1ton
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| | songorine Basic information |
| Product Name: | songorine | | Synonyms: | (20R)-21-Ethyl-1α,15β-dihydroxy-4-methyl-16-methylene-7α,20-cycloveatchan-12-one;Napellonine;Zongorine;(3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)-1-Ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-12,3,6a-ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one;Napellonin;Xuan-Wu 2;Songorine,BullatineG;ShiMoburo base I | | CAS: | 509-24-0 | | MF: | C22H31NO3 | | MW: | 357.49 | | EINECS: | 200-158-5 | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 509-24-0.mol |  |
| | songorine Chemical Properties |
| Melting point | 201-203℃ | | alpha | D20 -135.4° | | Boiling point | 535.8±50.0 °C(Predicted) | | density | 1.29 | | solubility | DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 5 mg/ml; Ethanol: slightly soluble | | form | A solid | | pka | 14.20±0.60(Predicted) | | color | White to off-white |
| Toxicity | LD50 in mice (mg/kg): 1575 orally, 630 s.c., 485 i.p., 142.5 i.v.; in rats (mg/kg): 407.5 i.p. (Bisset) |
| | songorine Usage And Synthesis |
| Chemical Properties | White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Chuanwu and Aconitum. | | Uses | Songorine is an extract from the Aconitum flavum root and may act as an inhibitor of JNK and p53 enhancing stimulation of fibroblast colony/cluster formation and proliferative activity of mesosomal precursors. | | in vivo | Songorine is investigated its efficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorineinhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax[1].
Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD50 and ED50 values of 142 mg and 7.3mg, respectively[2]. |
| | songorine Preparation Products And Raw materials |
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