- 3-Bromo-4-chloropyridine
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- $0.00 / 25KG
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2025-08-08
- CAS:36953-42-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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| | 3-Bromo-4-chloropyridine Basic information |
| | 3-Bromo-4-chloropyridine Chemical Properties |
| Melting point | 17.5-18.5 °C | | Boiling point | 115 °C(Press: 20 Torr) | | density | 1.19 | | refractive index | 1.453 | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | form | Liquid After Melting | | pka | 1.74±0.10(Predicted) | | color | Clear colorless to yellow | | InChI | InChI=1S/C5H3BrClN/c6-4-3-8-2-1-5(4)7/h1-3H | | InChIKey | QADXKWUCCGPQNR-UHFFFAOYSA-N | | SMILES | C1=NC=CC(Cl)=C1Br | | CAS DataBase Reference | 36953-42-1(CAS DataBase Reference) |
| Provider | Language |
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ACROS
| English |
| | 3-Bromo-4-chloropyridine Usage And Synthesis |
| Chemical Properties | Light yellow needles | | Uses |
3-Bromo-4-chloropyridine can be used as a bulk drug intermediate in pharmaceutical synthesis.
| | Synthesis | Example 543A Synthesis of 3-bromo-4-chlorofuro[3,2-c]pyridine: 4-Chlorofuro[3,2-c]pyridine (commercially available, 10.60 g, 69 mmol) was dissolved in carbon tetrachloride (135 mL) and cooled to -15°C. Bromine (12.13 g, 80 mmol) was added dropwise over 15 min. The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the solvent was removed under vacuum. The residue was dissolved in methanol (250 mL), 20% aqueous sodium hydroxide solution (35 mL) was added and stirring was continued for 1 hour at room temperature. Subsequently, methanol was removed under vacuum and the residue was partitioned between water (100 mL) and dichloromethane (50 mL). The organic layers were combined, dried over anhydrous magnesium sulfate, and the solvent was removed in vacuo to afford 3-bromo-4-chlorofuro[3,2-c]pyridine 15.45 g (96% yield) as a solid. Mass spectrum (ESI(+)) m/e 232,234 (M + H)+. | | References | [1] Patent: US2005/26944, 2005, A1 |
| | 3-Bromo-4-chloropyridine Preparation Products And Raw materials |
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