- Aescin IIA
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- $0.00 / 25kg
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2024-04-12
- CAS:158732-55-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 2000ton
- 82XHO27XQ8
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- $1.00 / 1kg
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2019-07-06
- CAS:158732-55-9
- Min. Order: 1kg
- Purity: 95%-99%
- Supply Ability: 1000kg
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| | escin IIa Basic information |
| Product Name: | escin IIa | | Synonyms: | escin IIa;82XHO27XQ8;AESCIN IIA;b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]-;β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-;EscinIC | | CAS: | 158732-55-9 | | MF: | C54H84O23 | | MW: | 1101.24 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 158732-55-9.mol |  |
| | escin IIa Chemical Properties |
| Boiling point | 1111.9±65.0 °C(Predicted) | | density | 1.45±0.1 g/cm3 (20 ºC 760 Torr) | | pka | 2.63±0.70(Predicted) |
| | escin IIa Usage And Synthesis |
| Uses | Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats[1][2]. | | in vivo | Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibits the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest[1].
Escin IIa (10-50 mg/kg;p.o.;) potently inhibits ethanol-induced gastric mucosal lesions[2]. | Animal Model: | Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)[1] | | Dosage: | 10-50 mg/kg | | Administration: | p.o. | | Result: | Showed a potent protective effect against ethanol-induced gastric lesions in rats.
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| | References | [1] Matsuda H, et al. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biol Pharm Bull. 1997;20(10):1092-1095. DOI:10.1248/bpb.20.1092
[2] Matsuda H, et al. Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats. Eur J Pharmacol. 1999;373(1):63-70. DOI:10.1016/s0014-2999(99)00249-6 |
| | escin IIa Preparation Products And Raw materials |
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