3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

Request For Quotation
3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:ASK1-IN-6
CAS:2407451-82-3
Package:50mg;10mg
3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Basic information
Product Name:3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-
Synonyms:3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-;ASK1-IN-6
CAS:2407451-82-3
MF:C17H14F4N6O2
MW:410.33
EINECS:
Product Categories:
Mol File:2407451-82-3.mol
3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Structure
3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Chemical Properties
density 1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka10.47±0.70(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Usage And Synthesis
UsesASK1-IN-6 (Compound 32) is a selective inhibitor for apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 25 nM. ASK1-IN-6 is blood brain barrier penetrate(rat Cl/Clu is 1.6/56 L/h/kg and Kp,uu is 0.46). ASK1-IN-6 exhibits anti-inflammatory avtivity and ameliorates the Alzheimer’s Disease in Tg4510 mouse model[1].
References[1] Jones JH, et al., Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo. J Med Chem. 2021 Oct 28;64(20):15402-15419. DOI:10.1021/acs.jmedchem.1c01458
3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Preparation Products And Raw materials
Tag:3-Pyridinecarboxamide, 5-fluoro-2-methoxy-N-[6-[4-[(1S)-2,2,2-trifluoro-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-(2407451-82-3) Related Product Information