| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:α2C adrenoceptor agonist 1
CAS:928115-79-1
Package:50mg;10mg
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| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Email: |
info@biorbyt.com |
| Products Intro: |
Product Name:α2C adrenoceptor agonist 1
CAS:928115-79-1
|
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| | α2C adrenoceptor agonist 1 Basic information |
| | α2C adrenoceptor agonist 1 Chemical Properties |
| Boiling point | 670.302±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.286±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 13.115±0.10(predicted) |
| | α2C adrenoceptor agonist 1 Usage And Synthesis |
| Uses | α2C adrenoceptor agonist 1 (Compound A) is an orally active, highly selective, and non-central nervous system penetrating agonist for the α2C-adrenoceptor, with EC50 and Ki values of 108 nM and 12 nM, respectively. α2C adrenoceptor agonist 1 can be used in the study of nasal congestion[1]. | | in vivo | α2C adrenoceptor agonist 1 (Compound A) (5 mg/kg; p.o.; single dose) exhibits poor brain permeability in Sprague-Dawley rats, with average values for Cmax, Tmax, and area under the curve being 0.8 μM, 0.7 h, and 2 μMh, respectively[1]. | | IC 50 | Alpha-2C adrenergic receptor: 108 nM (EC50); Alpha-2C adrenergic receptor: 12 nM (Ki) | | References | [1] Corboz MR, et al. Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A). J Pharmacol Exp Ther. 2011;337(1):256-266. DOI:10.1124/jpet.110.175794 |
| | α2C adrenoceptor agonist 1 Preparation Products And Raw materials |
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