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MeIm

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MeIm Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 021-13816613772 13816613772
Email: huahero21@sina.com
Products Intro: Product Name:MeIm
CAS:2043947-71-1
Purity:98% HPLC Package:1g
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:MeIm
CAS:2043947-71-1
Package:50mg/RMB 15300
MeIm Basic information
Product Name:MeIm
Synonyms:
CAS:2043947-71-1
MF:C22H22N8
MW:398.46
EINECS:
Product Categories:
Mol File:2043947-71-1.mol
MeIm Structure
MeIm Chemical Properties
Boiling point 780.2±70.0 °C(predicted)
density 1.31±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka5.79±0.25(predicted)
Safety Information
MSDS Information
MeIm Usage And Synthesis
UsesMeIm (compound 7) is a high-affinity PCSK9 targeting peptide mimetic with cholesterol-lowering activity. MeIm increases cellular uptake of LDL (EC50=6.04 μM) by inhibiting the binding of PCSK9 to LDLR (IC50=11.2 μM). MeIm can be used in the study of cardiovascular diseases[1][2].
References[1] Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024): 13. DOI:10.1038/s41392-023-01690-3
[2] Stucchi, et al. "Disrupting the PCSK9/LDLR protein–protein interaction by an imidazole-based minimalist peptidomimetic." Organic & Biomolecular Chemistry 14.41 (2016): 9736-9740. DOI:10.1039/c6ob01642a
MeIm Preparation Products And Raw materials
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