羟基鱼藤素
| 中文名称 | 羟基鱼藤素 |
|---|---|
| 中文同义词 | 灰叶草素, 羟基鱼藤素;灰叶素;化合物 T13126;羟基鱼藤素/灰叶草素 |
| 英文名称 | (-)-TEPHROSIN |
| 英文同义词 | 13,13a-Dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one;Hydroxydeguelin;Isotephrosin;Deguelinol I;Tephrosin (synthetic);3H-Bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7- (7aH)-one,13,13a-dihydro-7a-hydroxy-9,10- dimethoxy-3,3-dimethyl-,(7aR,13aR)-;Tephrosin >=95% (LC/MS-ELSD);(-)-TEPHROSIN USP/EP/BP |
| CAS号 | 76-80-2 |
| 分子式 | C23H22O7 |
| 分子量 | 410.42 |
| EINECS号 | |
| 相关类别 | 标准品;植物提取物;标准品 -对照药材;黄酮;Miscellaneous Natural Products |
| Mol文件 | 76-80-2.mol |
| 结构式 |  |
羟基鱼藤素 性质
| 熔点 | 198° (218-220°) |
|---|---|
| 沸点 | 450.42°C (rough estimate) |
| 密度 | 1.2284 (rough estimate) |
| 折射率 | 1.5300 (estimate) |
| 储存条件 | -20°C |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形态 | 水晶。 |
| 酸度系数(pKa) | 10.47±0.40(Predicted) |
| 颜色 | 白色至米白色 |
| 主要应用 | metabolomics vitamins, nutraceuticals, and natural products |
| InChI | 1S/C23H22O7/c1-22(2)8-7-12-15(30-22)6-5-13-20(12)29-19-11-28-16-10-18(27-4)17(26-3)9-14(16)23(19,25)21(13)24/h5-10,19,25H,11H2,1-4H3/t19-,23-/m1/s1 |
| InChIKey | AQBZCCQCDWNNJQ-AUSIDOKSSA-N |
| SMILES | COc1cc2OC[C@H]3Oc4c(ccc5OC(C)(C)C=Cc45)C(=O)[C@@]3(O)c2cc1OC |
Tephrosin 是一种天然类胡萝卜素，具有较强的抗肿瘤活性。Tephrosin 通过诱导受体内化来诱导 EGFR 和 ErbB2 的降解。
Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) .