| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
|
| | IAV-IN-3 Basic information |
| Product Name: | IAV-IN-3 | | Synonyms: | IAV-IN-3;Pyrido[1,2-b]pyrrolo[1,2-e][1,2,5]triazepine-5,7-dione, 11-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-1,2,3,11,12,12a-hexahydro-6-hydroxy-, (12aR)- | | CAS: | 3049492-11-4 | | MF: | C25H21F2N3O3S | | MW: | 481.52 | | EINECS: | | | Product Categories: | | | Mol File: | 3049492-11-4.mol |  |
| | IAV-IN-3 Chemical Properties |
| Boiling point | 629.5±65.0 °C(predicted) | | density | 1.57±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 4.50±1.00(predicted) |
| | IAV-IN-3 Usage And Synthesis |
| Uses | IAV-IN-3 (Compound (R,S)-16s) is an anti-influenza A virus (IAV) agent (EC50 = 0.134 μM) with weak cytotoxicity (CC50 = 15.35 μM for MDCK cells). IAV-IN-3 inhibits IAV polymerase with an IC50 of 0.045 μM[1]. | | References | [1] Zhang L, et al. Design and synthesis of 7-membered lactam fused hydroxypyridinones as potent metal binding pharmacophores (MBPs) for inhibiting influenza virus PAN endonuclease. Eur J Med Chem. 2024 Jul 1;276:116639. DOI:10.1016/j.ejmech.2024.116639 |
| | IAV-IN-3 Preparation Products And Raw materials |
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