- Menadiol diacetate
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- $285.00
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2026-05-15
- CAS:573-20-6
- Min. Order: 1KG
- Purity: 99
- Supply Ability: 100kg
- Vitamin K4
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- $55.00
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2026-05-11
- CAS:573-20-6
- Purity: 99.84%
- Supply Ability: 10g
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| | Menadiol diacetate Basic information |
| | Menadiol diacetate Chemical Properties |
| Melting point | 113 °C | | Boiling point | 361.52°C (rough estimate) | | density | 1.2105 (rough estimate) | | refractive index | 1.4872 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | Water Solubility | Insoluble in water | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml | | form | powder to crystal | | color | White to Almost white | | InChI | InChI=1S/C15H14O4/c1-9-8-14(18-10(2)16)12-6-4-5-7-13(12)15(9)19-11(3)17/h4-8H,1-3H3 | | InChIKey | RYWSYCQQUDFMAU-UHFFFAOYSA-N | | SMILES | C1(OC(=O)C)=C2C(C=CC=C2)=C(OC(=O)C)C=C1C | | CAS DataBase Reference | 573-20-6(CAS DataBase Reference) |
| WGK Germany | WGK 3 | | RTECS | QJ5250000 | | HS Code | 2936.29.5050 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Dam. 1 |
| | Menadiol diacetate Usage And Synthesis |
| Uses | Vitamin K4, is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system. | | Definition | ChEBI: Acetomenaphthone is a member of naphthalenes. | | Biological Activity | Vitamin K4 elicits anti-cancer functionality and induces apoptosis in prostate carcinoma. | | Synthesis | General procedure for the synthesis of vitamin K4 from 2-methyl-1,4-naphthoquinone (20.0 g) and acetic anhydride (29.65 g): 2-methyl-1,4-naphthoquinone was first dissolved in ethyl acetate (200 g). Subsequently, acetic anhydride, 4-dimethylaminopyridine (DMAP, 1.42 g), and palladium/carbon catalyst (Pd/C, 0.6 g) were added to the solution. The reaction mixture was stirred at room temperature in a hydrogen atmosphere overnight. Upon completion of the reaction, the Pd/C catalyst was removed by filtration. The filtrate was washed with brine and the organic layer was separated. The organic layer was concentrated and recrystallized in a solvent mixture of water (60 g) and isopropanol (IPA, 80 g) to yield 28.0 g of vitamin K4 as white crystals (yield: 84.2%, HPLC purity: 99.8%). The structure of the compound was characterized by 1H-NMR with the following chemical shifts: δ 2.27 (s, 3H), 2.46 (s, 3H), 2.50 (s, 3H), 7.27 (s, 1H), 7.55-7.62 (m, 2H), 7.85-7.89 (d, 2H). | | References | [1] Patent: WO2016/60670, 2016, A1. Location in patent: Paragraph 0036-0041
[2] Patent: TW2016/15603, 2016, A. Location in patent: Paragraph 0049-0051
[3] Journal of Crystallographic and Spectroscopic Research, 1989, vol. 19, # 2, p. 307 - 316
[4] Archiv der Pharmazie, 1973, vol. 306, # 4, p. 257 - 267 |
| | Menadiol diacetate Preparation Products And Raw materials |
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