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| | (S)-5-hydroxy-6-methoxy Duloxetine (maleate) Basic information |
| | (S)-5-hydroxy-6-methoxy Duloxetine (maleate) Chemical Properties |
| solubility | DMF: Soluble
DMSO: Soluble
Ethanol: Soluble
Methanol: Soluble |
| | (S)-5-hydroxy-6-methoxy Duloxetine (maleate) Usage And Synthesis |
| Description | (S)-5-hydroxy-6-methoxy Duloxetine is an active metabolite of the serotonin (5-HT) and norepinephrine reuptake inhibitor (S)-duloxetine (Item No. 14317).1,2 It is formed from (S)-duloxetine via a 5- or 6-hydroxy duloxetine intermediate, which is formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6, and a catechol duloxetine intermediate.2 (S)-5-hydroxy-6-methoxy Duloxetine inhibits the 5-HT transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) in lipid membranes (Kis = 266, 920, and 2,814 nM, respectively, for the human transporters).1WARNING This product is not for human or veterinary use. | | References | [1] F. KUO. Synthesis and biological activity of some known and putative duloxetine metabolites[J]. Bioorganic & Medicinal Chemistry Letters, 2004, 14 13: Pages 3481-3486. DOI: 10.1016/j.bmcl.2004.04.066
[2] MARY PAT KNADLER. Duloxetine: clinical pharmacokinetics and drug interactions.[J]. Clinical Pharmacokinetics, 2011, 50 5: 281-294. DOI: 10.2165/11539240-000000000-00000 |
| | (S)-5-hydroxy-6-methoxy Duloxetine (maleate) Preparation Products And Raw materials |
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