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| | N,N-Dimethylformamide dimethyl acetal Basic information |
| Product Name: | N,N-Dimethylformamide dimethyl acetal | | Synonyms: | 1,1-dimethoxy-n,n-dimethyl-methanamin;Dimethoxy(dimethylamino)methane;Dimethoxy-N,N-dimethylmethanamine;N-(Dimethoxymethyl)dimethylamine;N,N-Dimethylfirmanmidedimethylacetal;N,N-Dimethylformamide dimethyl acetal, 95% (1,1-Dimethoxytrimethylamine);N,N-Dimethylformamide dimethyl acetal, ca 97%;Methanamine, 1,1-dimethoxy-N,N-dimethyl- | | CAS: | 4637-24-5 | | MF: | C5H13NO2 | | MW: | 119.16 | | EINECS: | 225-063-3 | | Product Categories: | (intermediate of zaleplon);Aliphatics;blocks;BuildingBlocks;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Protecting Agents for Hydroxyl and Amino Groups;Protecting Agents, Phosphorylating Agents & Condensing Agents;Analytical Chemistry;Esterification & Alkylation (GC Derivatizing Reagents);GC Derivatizing Reagents;N,N-Dimethylformamide Dialkylacetals (GC Derivatizing Reagents);4637-24-5;bc0001 | | Mol File: | 4637-24-5.mol |  |
| | N,N-Dimethylformamide dimethyl acetal Chemical Properties |
| Melting point | -85°C | | Boiling point | 102-103 °C/720 mmHg (lit.) | | density | 0.897 g/mL at 25 °C (lit.) | | vapor pressure | 34.5hPa at 20℃ | | refractive index | n20/D 1.396(lit.) | | Fp | 45 °F | | storage temp. | Store below +30°C. | | solubility | Miscible with most organic solvents. | | pka | 5.00±0.50(Predicted) | | form | Solid | | color | White to off-white | | PH | 7 (H2O) | | explosive limit | 1.3-17.7%(V) | | Water Solubility | hydrolysis | | Sensitive | Moisture Sensitive | | BRN | 506020 | | Exposure limits | ACGIH: TWA 200 ppm; STEL 250 ppm (Skin)
OSHA: TWA 200 ppm(260 mg/m3)
NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3) | | InChI | 1S/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3 | | InChIKey | ZSXGLVDWWRXATF-UHFFFAOYSA-N | | SMILES | COC(OC)N(C)C | | LogP | 0.750 (est) | | CAS DataBase Reference | 4637-24-5(CAS DataBase Reference) | | NIST Chemistry Reference | Methanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5) | | EPA Substance Registry System | Methanamine, 1,1-dimethoxy-N,N-dimethyl- (4637-24-5) |
| Hazard Codes | F,Xn,Xi | | Risk Statements | 11-22-36/37/38-36/38-20-20/21/22-10-52 | | Safety Statements | 16-26-36/37-36/37/39-33-29-7/9 | | RIDADR | UN 3271 3/PG 2 | | WGK Germany | 1 | | F | 21 | | Autoignition Temperature | 155 °C | | TSCA | TSCA listed | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29225000 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 4 Inhalation
Eye Dam. 1
Flam. Liq. 2
Skin Sens. 1 | | Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
| | N,N-Dimethylformamide dimethyl acetal Usage And Synthesis |
| Chemical Properties | clear colourless liquid | | Uses | 1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes. | | Uses | N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates. | | Uses | Used to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates. | | Definition | ChEBI: An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applica
ions | | General Description | Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters. | | Flammability and Explosibility | Highly flammable | | reaction suitability | reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications | | Synthesis | A method for synthesizing N,N-dimethylformamide dimethyl acetal, comprising the steps of (1) heating N,N-dimethylformamide to 70°C, mixing with dimethyl sulfate in a molar ratio of 1:1 and reacting for 4 hours after the end of dropwise addition to obtain the imine complex, and then cooling to room temperature; (2) adding solid sodium methanol to 200 solvent oil, dispersing it by ultrasonication, adjusting the temperature to 25 ℃ and maintained, dropwise addition of the imine complex, the reaction for 2 hours and then filtered, the filtrate often pressure fractionation, collection of 105-108 ℃ fraction, to obtain N,N-dimethylformamide dimethyl acetal, the yield was 75.3%, purity of 97%; wherein the molar ratio of sodium methanol to the imine complex is 1:1. The synthesis of the N,N-dimethylformamide dimethyl acetal of Example 6 is the same as that of Example 2, the The difference is that the organic solvent of this embodiment is a mixed solvent oil: D40 solvent oil, D60 solvent oil and 260 solvent oil, with a volume ratio of 2:1:1, to obtain N,N-dimethylformamide dimethyl acetal with a yield of 85.4% and a purity of 97%. | | References | [1] Patent: CN106083611, 2016, A. Location in patent: Paragraph 0034-0037; 0048-0049 |
| | N,N-Dimethylformamide dimethyl acetal Preparation Products And Raw materials |
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