- Boc-gly
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- $0.00 / 1kg
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2026-01-23
- CAS:4530-20-5
- Min. Order: 1kg
- Purity: 98+
- Supply Ability: 1T
- BOC-Glycine
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- $10.00 / 1KG
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2026-01-05
- CAS:4530-20-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5tons
- BOC-Glycine
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- $0.00 / 25KG
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2025-12-01
- CAS:4530-20-5
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 10000KGS
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| | BOC-Glycine Basic information |
| | BOC-Glycine Chemical Properties |
| Melting point | 86-89 °C(lit.) | | Boiling point | 306.47°C (rough estimate) | | density | 1.2843 (rough estimate) | | refractive index | 1.4353 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | pka | 4.00±0.10(Predicted) | | form | Powder | | color | White to off-white | | Water Solubility | soluble | | BRN | 1101514 | | Major Application | peptide synthesis | | InChI | InChI=1S/C7H13NO4/c1-7(2,3)12-6(11)8-4-5(9)10/h4H2,1-3H3,(H,8,11)(H,9,10) | | InChIKey | VRPJIFMKZZEXLR-UHFFFAOYSA-N | | SMILES | C(O)(=O)CNC(OC(C)(C)C)=O | | CAS DataBase Reference | 4530-20-5(CAS DataBase Reference) | | EPA Substance Registry System | Glycine, N-[(1,1-dimethylethoxy)carbonyl]- (4530-20-5) |
| | BOC-Glycine Usage And Synthesis |
| Chemical Properties | White To Off-White Powder | | Uses | BOC-Glycine is used in the composition of drugs containing Ketoprofen, and Sodium hyaluronate as antiinflammatory agents. | | Uses | Boc-Gly-OH can be used:
- For the esterification reaction to synthesize N-Boc amino acid esters for peptide chemistry.
- For the synthesis of tripeptide H-Gly-Pro-Glu-OH, analogs of neuroprotective drugs.
- As a promoter for the allylation of hydrazones and isatin.
| | Synthesis Reference(s) | Tetrahedron Letters, 16, p. 4393, 1975 DOI: 10.1016/S0040-4039(00)91133-X | | reaction suitability | reaction type: Boc solid-phase peptide synthesis | | Synthesis | 1. 18.1g L-glycine, 100ml water was added to the reaction flask and stirred. Add 16g of sodium hydroxide configured 0.01mol/L alkaline solution adjusted to alkaline. Then 8g of (Boc)2O was added and reacted for 2 hours, then 8g of (Boc)2O was added and reacted for 2 hours and finally 9g of (Boc)2O was added and reacted for 4 hours.
2. The impurities were extracted three times with hexane 12 ml/time. 3 mol/L hydrochloric acid was used to adjust the PH=3 and then the product was extracted three times with dioxane 0.6 L/time. Combine the ester layers and wash with brine to neutral. Add 15 g of anhydrous sodium sulfate to dry for 10 hours.
3. Filter, concentrate the filtrate dry under reduced pressure, add 60 ml of hexane and stir to crystallize. Centrifuged out the product and dried. Obtained product 25.0 g. Yield 93.87%.
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| | BOC-Glycine Preparation Products And Raw materials |
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