| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:CI 1020
CAS:162256-50-0
Package:100Mg,10Mg
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| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:CI 1020;3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-Methoxyphenyl)-4-[(3,4,5-triMethoxyphenyl)Methyl]-2(5H)-furanone
CAS:162256-50-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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CI 1020 manufacturers
- CI 1020
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- $1670.00 / 25mg
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2024-10-24
- CAS:162256-50-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | CI 1020 Basic information |
| | CI 1020 Chemical Properties |
| storage temp. | Store at +4°C | | solubility | Soluble to 50 mM in DMSO | | form | Powder |
| | CI 1020 Usage And Synthesis |
| Uses | A novel endothelin-A receptor antagonist, in hypoxic pulmonary hypertension. | | Biological Activity | Highly selective, orally active, non-peptide endothelin-A receptor (ET A ) antagonist (IC 50 values are 0.3 and 480 nM for ET A and ET B receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration. | | in vivo | CI-1020 (30 mg/kg, p.o.) represents full inhibition of the ET-A and has no significant effect on basal blood pressure in normotensive rats[2].
CI-1020 (40 mg/kg, p.o.) attenuates established pulmonary hypertension in rats previously exposed to chronic hypoxia[4]. | Animal Model: | normal rats [2] | | Dosage: | 30 mg/kg | | Administration: | oral administration (p.o.) | | Result: | Inhibited the ET-A and has no significant effect on basal blood pressure in normotensive rats. |
| Animal Model: | basal blood pressure in normotensive rats[4] | | Dosage: | 40 mg/kg/day | | Administration: | oral administration (p.o.) | | Result: | Reduced the increase in RV/LV+S and the percentage DEL induced by chronic hypoxia.
Lowered the increase in pulmonary resistance in isolated perfused lungs significantly.
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| | IC 50 | ETA: 0.3 nM (IC50) |
| | CI 1020 Preparation Products And Raw materials |
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