DIPEPTIDYLPEPTIDASE IV INHIBITOR I

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DIPEPTIDYLPEPTIDASE IV INHIBITOR I Basic information
Product Name:DIPEPTIDYLPEPTIDASE IV INHIBITOR I
Synonyms:DIPEPTIDYLPEPTIDASE IV INHIBITOR I
CAS:
MF:C19H32F3N3O6
MW:455.47
EINECS:
Product Categories:
Mol File:Mol File
DIPEPTIDYLPEPTIDASE IV INHIBITOR I Structure
DIPEPTIDYLPEPTIDASE IV INHIBITOR I Chemical Properties
storage temp. 2-8°C
form solid
color white
Water Solubility water: 1mg/mL
DMSO: 5mg/mL
Safety Information
MSDS Information
DIPEPTIDYLPEPTIDASE IV INHIBITOR I Usage And Synthesis
UsesDipeptidyl peptidase IV inhibitor I has been used in acute in vivo studies to assess rapid plasma glucagon-like peptide (GLP-1) responses to specified secretory agents in mice.
Biochem/physiol ActionsDipeptidyl peptidase IV is a key enzyme involved in the regulation of incretin hormone levels in the gastrointestinal tract. Incretin hormones, such as glucagon like peptide (GLP-1) and glucose-dependent insulinotopic hormone (GIP) / gastoric inhibitory peptide, cause the glucose stimulated release of insulin. This allows the endocrine system to preemptively stimulate release insulin in response to ingestion of high sugar foods. Type 2 diabetics demonstrate a greatly reduced incretin induced insulin release response. This response in hyperglycemic conditions is counterbalanced by the rapid rate of degradation of these incretin hormones by dipeptidyl peptidase IV in normal conditions. Inhibition of dipeptidyl peptidase IV results in longer lifetime of the incretin hormones in the GI tract and thus prolonged stimulation of insulin production. Specific dipeptidyl peptidase inhibitors are actively being explored as drug targets for treating type 2 diabetes and several candidates are actively in clinical trial. Dipeptidyl peptidase IV (Diprotin A) inhibits both endo- and exopeptidase activities of Dipeptidyl peptidase IV.
DIPEPTIDYLPEPTIDASE IV INHIBITOR I Preparation Products And Raw materials
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