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| Product Name: | HUMAN IGF-II | | Synonyms: | (2S)-1-acetyl-N-[(2S,3R)-1-[[(2S)-1-[[(2S)-3,3-dihydroxy-1-(4-hydroxyphenyl)butan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]pyrrolidine-2-carboxamide;INSULIN-LIKE GROWTH FACTOR-II;INSULIN-LIKE GROWTH FACTOR-II HUMAN;INSULIN-LIKE GROWTH FACTOR-II, HUMAN, RECOMBINANT;IGF-II, HUMAN;IGF-2 HUMAN;IGF-II;HUMAN INSULIN-LIKE GROWTH FACTOR II | | CAS: | 96081-16-2 | | MF: | C24H36N4O9 | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![HUMAN IGF-II Structure]() |
| | HUMAN IGF-II Chemical Properties |
| storage temp. | -20°C | | form | lyophilized powder | | biological source | human |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | HUMAN IGF-II Usage And Synthesis |
| Biochem/physiol Actions | Insulin-like growth factor II (IGF-II) also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. Expression of IGF-II is highest in fetal tissues, where it is believed to play a major role in overall growth and development. After birth IGF-II expression decreases to much lower levels in a variety of tissues. IGF-II is produced also in several tumors. IGF-II binds to IGF-II receptor (IGF-IIR), to IGF-IR and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-IR. However, during embryogenesis the roles of both IGF-IIR and IR may be significant in promoting normal growth. | | Description | Insulin-Like Growth Factor- II Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 67 amino acids and having a molecular mass of 7.5k Dalton. IGF-II is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | IGF-2 is a member of the INS family of polypeptide growth factors that is involved in development and growth. It is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. |
| | HUMAN IGF-II Preparation Products And Raw materials |
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