- Isoquinolin-6-ol
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- $10.00 / 1kg
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2023-08-09
- CAS:7651-82-3
- Min. Order: 1kg
- Purity: 99.99%
- Supply Ability: 50000tons
- Isoquinolin-6-ol
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- $1.10 / 1g
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2022-03-07
- CAS:7651-82-3
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
- Isoquinolin-6-ol
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- $5.50 / 1KG
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2020-01-15
- CAS:7651-82-3
- Min. Order: 1IU
- Purity: 98%min
- Supply Ability: 1kg-100kg
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| | Isoquinolin-6-ol Basic information |
| | Isoquinolin-6-ol Chemical Properties |
| Melting point | 220 °C | | Boiling point | 332.1±15.0 °C(Predicted) | | density | 1.260±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | solid | | pka | 9.15±0.10(Predicted) | | color | Pale yellow | | InChI | InChI=1S/C9H7NO/c11-9-2-1-8-6-10-4-3-7(8)5-9/h1-6,11H | | InChIKey | GPVPDRHTRGTSIH-UHFFFAOYSA-N | | SMILES | C1C2=C(C=C(O)C=C2)C=CN=1 | | CAS DataBase Reference | 7651-82-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Hazard Note | Irritant | | HS Code | 2933499090 |
| | Isoquinolin-6-ol Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder | | Uses | 6-Hydroxyisoquinoline is used in proteomics research such as in preparation of isoquinoline derivatives which act as protease inhibitors against trypsin. It was also used as a reagent in the study of a novel series of compounds that act as Wnt signaling pathway inhibitors and obtained by scaffold hybridization strategy from two known porcupine inhibitor classes. | | Synthesis | (c) 6-Methoxyisoquinoline (16 g, 0.1 mol) was mixed with 48% aqueous hydrobromic acid (600 mL) and heated to reflux for 6 hours. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was dissolved in water (H2O) and the pH was adjusted to alkaline with solid sodium carbonate (Na2CO3). The precipitated solid product was collected by filtration and recrystallized with isopropanol to give the final 6-hydroxyisoquinoline (12 g, 82% yield) with a melting point of 205°C. Literature reports a melting point of 218°-220°C (Lit.* 220°C). | | References | [1] Patent: US4812573, 1989, A
[2] Patent: WO2004/43904, 2004, A1. Location in patent: Page 59
[3] Patent: WO2004/43931, 2004, A1. Location in patent: Page 36-37
[4] Journal of the American Chemical Society, 1947, vol. 69, p. 1944
[5] European Journal of Organic Chemistry, 2003, # 9, p. 1681 - 1686 |
| | Isoquinolin-6-ol Preparation Products And Raw materials |
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