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| | Difluoxacin hydrochloride Chemical Properties |
| Melting point | >245°C (dec.) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in aqueous buffer | | form | powder | | color | White to off-white | | Major Application | forensics and toxicology
pharmaceutical (small molecule) | | InChI | InChI=1S/C21H19F2N3O3.ClH/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;/h2-5,10-12H,6-9H2,1H3,(H,28,29);1H | | InChIKey | JFMGBGLSDVIOHL-UHFFFAOYSA-N | | SMILES | C12C=C(C(F)=CC=1C(C(C(=O)O)=CN2C1=CC=C(F)C=C1)=O)N1CCN(C)CC1.Cl | | CAS DataBase Reference | 91296-86-5(CAS DataBase Reference) |
| WGK Germany | 3 | | RTECS | VB2008975 | | Storage Class | 11 - Combustible Solids |
| | Difluoxacin hydrochloride Usage And Synthesis |
| Brand Name(s) in US | Dicural
| | Description | Difloxacin is a fluoroquinolone antibiotic. It is active against isolates of anaerobic bacteria, including B. fragilis, as well as Fusobacterium and Actinomyces species with MIC values ranging from ≤0.125 to 8 μg/ml. It eliminates E. coli and B. fragilis infection in a rat intra-abdominal abscess model when administered at a dose of 40 mg/kg three times per day. | | Chemical Properties | Off-White to Pale Yellow Solid | | Uses | antibacterial, DNA gyrase inhibitor | | Uses | A quinolone antibacterial compound. Structurally related to norfloxacin | | Uses | A fluoroquinolone antibacterial structurally related to norfloxacin. | | References | [1] M B BANSAL H T. Activity of difloxacin (A-56619) and A-56620 against clinical anaerobic bacteria in vitro.[J]. Antimicrobial Agents and Chemotherapy, 1987, 31 4: 619-621. DOI: 10.1128/aac.31.4.619
[2] H THADEPALLI S K C S V Gollapudi. Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess.[J]. Antimicrobial Agents and Chemotherapy, 1986, 30 4: 574-576. DOI: 10.1128/aac.30.4.574 |
| | Difluoxacin hydrochloride Preparation Products And Raw materials |
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