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| | α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Basic information |
| Product Name: | α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 | | Synonyms: | 2-Ketopentanedioic acid-d6;α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6;2-Ketoglutaric acid-d6;α-Ketoglutaric acid-d6;α-Ketopentanoic acid-d6;2-oxopentanedioic-3,3,4,4-d4acid-d2;EOS-60378;ALPHA-KETOGLUTARIC ACID (D6, 98%) | | CAS: | 1173021-86-7 | | MF: | C5D6O5 | | MW: | 152.135110668 | | EINECS: | | | Product Categories: | | | Mol File: | 1173021-86-7.mol |  |
| | α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Chemical Properties |
| Melting point | 114-117 °C | | form | Solid | | color | White to off-white | | InChI | 1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/i1D2,2D2/hD2 | | InChIKey | KPGXRSRHYNQIFN-DTDGFSOZSA-N | | SMILES | [2H]OC(=O)C(=O)C([2H])([2H])C([2H])([2H])C(=O)O[2H] | | CAS Number Unlabeled | 328-50-7 |
| Hazard Codes | Xi | | Risk Statements | 37/38-41 | | Safety Statements | 26-39 | | WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Usage And Synthesis |
| Uses | 2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. DOI:10.1128/MMBR.00038-15
[3] Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec105(Pt 3):1654-1662. DOI:10.1016/j.ijbiomac.2016.12.015 |
| | α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Preparation Products And Raw materials |
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