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BOC Sciences |
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- Piperiacetildenafil
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2020-02-26
- CAS: 147676-50-4
- Min. Order: 10g
- Purity: 99.0%+
- Supply Ability: 100 tons
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| | Piperiacetildenafil Basic information |
| Product Name: | Piperiacetildenafil | | Synonyms: | Piperiacetildenafil;5-(2-Ethoxy-5-piperidinoacetylphenyl)-1-Methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyriMidin-7-one;5-[2-Ethoxy-5-[2-(1-piperidinyl)acetyl]phenyl]-1,6-dihydro-1-Methyl-3-propyl-7H-pyrazolo[4,3-d]pyriMidin-7-one;Piperiacetidenafil;7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[2-(1-piperidinyl)acetyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-;Piperiacetildenafil ISO 9001：2015 REACH;J2.357.565E;Piperidino acetildenafil | | CAS: | 147676-50-4 | | MF: | C24H31N5O3 | | MW: | 437.53 | | EINECS: | | | Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 147676-50-4.mol |  |
| | Piperiacetildenafil Chemical Properties |
| Melting point | 149-152oC | | density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | pka | 10.09±0.20(Predicted) | | form | Solid | | color | White to Off-White |
| | Piperiacetildenafil Usage And Synthesis |
| Uses | Piperiacetildenafil is an intermediate in the preparation of pyrazolopyrimidinones used in male sexual enhancement formulas | | Synthesis | Piperacetildenafil was prepared as follows: piperidine (0.22 ml, 0.0022 mol) was added to a stirred 5-(5-bromoacetyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3 -d]pyrimidin-7- one (Preparation 8, 0.95 g, 0.0022 mol) and anhydrous potassium carbonate (0.6 g , 0.0044 mol) in acetonitrile (50 ml). After 18 h, the mixture was evaporated under vacuum, the residue was dissolved in water (50 ml) and the solution was extracted with ethyl acetate (3 x 30 ml). The organic extracts were combined, washed with brine (3 x 20 ml), dried (Na2SO4 ) and vacuum evaporated. The resulting yellow solid was chromatographically separated on silica gel (12 g) using an elution gradient of methanol in dichloromethane (0-2% methanol) to give an off-white solid. Crystallization with ethyl acetate-hexane gave the title compound piperacetildenafil as an off-white powder (0.27 g, 28%), m.p. |
| | Piperiacetildenafil Preparation Products And Raw materials |
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