- Boc-D-prolinal
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- $1.10 / 25KG
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2025-10-13
- CAS:73365-02-3
- Min. Order: 1KG
- Purity: 99%min
- Supply Ability: 100KG
- N-Boc-D-Prolinal
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- $0.00 / 1kg
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2024-11-26
- CAS:73365-02-3
- Min. Order: 0.1kg
- Purity: 98%(GC);99%ee
- Supply Ability: 500kg
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| | N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Basic information |
| | N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Chemical Properties |
| alpha | +83°(23℃, neat) | | Boiling point | 228 °C(lit.) | | density | 1.059 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.461(lit.) | | Fp | >230 °F | | storage temp. | -20°C | | pka | -3.03±0.40(Predicted) | | form | Liquid | | color | Colorless to yellow | | Specific Gravity | 1.059 | | Optical Rotation | [α]23/D +83°, neat | | Sensitive | Air Sensitive | | Major Application | peptide synthesis | | InChI | InChI=1S/C10H17NO3/c1-10(2,3)14-9(13)11-6-4-5-8(11)7-12/h7-8H,4-6H2,1-3H3/t8-/m1/s1 | | InChIKey | YDBPZCVWPFMBDH-MRVPVSSYSA-N | | SMILES | N1(C(OC(C)(C)C)=O)CCC[C@@H]1C=O |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 29339980 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Usage And Synthesis |
| Chemical Properties | Clear colorless to yellow liquid | | Uses | peptide synthesis | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | 1. tert-Butyl (2R)-2-formylpyrrolidine-1-carboxylate (15.9 g, 37.4 mmol) was added in batches to a stirring solution of tert-Butyl (2R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate (5.0 g, 24.9 mmol) in dichloromethane (75 mL) under nitrogen protection over a 5-minute dosing period. 2. The reaction mixture was stirred for 1 hr. to form a suspension.3. The suspension was filtered through a diatomaceous earth pad and the filter cake was washed with dichloromethane (100 mL).4. The filtrate was concentrated under pressure to give the crude product.5. The crude product was purified by neutral silica gel column chromatography to give BOC-D-prolinyl aldehyde (4.4 g, 89% yield) using 12% ethyl acetate/hexanes as eluent. | | References | [1] Patent: WO2015/120390, 2015, A1. Location in patent: Page/Page column 97; 178
[2] Tetrahedron Letters, 1997, vol. 38, # 37, p. 6479 - 6482
[3] Patent: WO2015/118342, 2015, A1. Location in patent: Page/Page column 94; 95
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 12, p. 3190 - 3198
[5] Tetrahedron Letters, 1990, vol. 31, # 28, p. 3957 - 3960 |
| | N-(TERT-BUTOXYCARBONYL)-D-PROLINAL Preparation Products And Raw materials |
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