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| | Neochinulin A Basic information |
| Product Name: | Neochinulin A | | Synonyms: | (3S)-3α-Methyl-6-[(Z)-[2-(1,1-dimethyl-2-propenyl)-1H-indole-3-yl]methylene]hexahydropyrazine-2,5-dione;(6S)-3-[(Z)-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]methylene]-6-methyl-2,5-piperazinedione;Neochinulin A;Neoechinulin A;2,5-Piperazinedione, 3-[[2-(1,1-dimethyl-2-propen-1-yl)-1H-indol-3-yl]methylene]-6-methyl-, (3Z,6S)-;(3S,6Z)-3-Methyl-6-{[2-(2-methyl-3-buten-2-yl)-1H-indol-3-yl]methylene}-2,5-piperazinedione;(S,Z)-3-Methyl-6-((2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl)methylene)piperazine-2,5-dione | | CAS: | 51551-29-2 | | MF: | C19H21N3O2 | | MW: | 323.39 | | EINECS: | | | Product Categories: | | | Mol File: | 51551-29-2.mol |  |
| | Neochinulin A Chemical Properties |
| Melting point | 272-275 °C | | Boiling point | 655.7±55.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | storage temp. | 4°C, away from moisture and light | | pka | 11.96±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | Neochinulin A Usage And Synthesis |
| Uses | Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice[1][2]. | | in vivo | In the Y-maze test, the intracerebroventicular (i.c.v.) administration of LPS (10 μg/mouse) significantly decreased spontaneous alternation behavior, which was prevented by the prior administration of neoechinulin A (300ng/mouse, i.c.v.)[1]. | | References | [1] Humbert M, et al. Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One. 2010;5(3):e9430. Published 2010 Mar 4. DOI:10.1371/journal.pone.0009430
[2] Kim KS, et al. Anti-inflammatory effect of neoechinulin a from the marine fungus Eurotium sp. SF-5989 through the suppression of NF-кB and p38 MAPK Pathways in lipopolysaccharide-stimulated RAW264.7 macrophages. Molecules. 2013;18(11):13245-13259. Publish DOI:10.3390/molecules181113245
[3] Dewapriya P, et al. Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity. Neurotoxicology. 2013;35:30-40. DOI:10.1016/j.neuro.2012.12.004 |
| | Neochinulin A Preparation Products And Raw materials |
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