(6R)-6,7,8,9-Tetrahydro-6β,7α-dihydroxy-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione

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(6R)-6,7,8,9-Tetrahydro-6β,7α-dihydroxy-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione Basic information
Product Name:(6R)-6,7,8,9-Tetrahydro-6β,7α-dihydroxy-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione
Synonyms:(6R,7R)-6,7,8,9-Tetrahydro-6,7-dihydroxy-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione;Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-6,7-dihydroxy-1,6-dimethyl-, (6R,7R)-(-)-;(-)-Tanshindiol C;Tanshindiol C
CAS:97465-71-9
MF:C18H16O5
MW:312.31664
EINECS:
Product Categories:
Mol File:97465-71-9.mol
(6R)-6,7,8,9-Tetrahydro-6β,7α-dihydroxy-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione Structure
(6R)-6,7,8,9-Tetrahydro-6β,7α-dihydroxy-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione Chemical Properties
Boiling point 561.5±50.0 °C(Predicted)
density 1.436±0.06 g/cm3(Predicted)
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form powder
pka13.76±0.40(Predicted)
color Red
Safety Information
MSDS Information
(6R)-6,7,8,9-Tetrahydro-6β,7α-dihydroxy-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione Usage And Synthesis
DescriptionTanshindiol C exhibits most powerful cytotoxic effects against tested tumor cells. Tanshinones plays significant roles in the inhibition and induction of several CYP450 isozymes.
UsesTanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. Tanshindiol C possesses anti-cancer activity, and can be used for atherosclerosis research[1][2].
targetP450 (e.g. CYP17)
IC 50EZH2: 0.55 μM (IC50); SIRT1
References[1] Yuyu Yang, et al. Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway. Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):882-890. DOI:10.1016/j.bbadis.2017.12.033
[2] Jimin Woo, et al. Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2486-92. DOI:10.1016/j.bmcl.2014.04.010
(6R)-6,7,8,9-Tetrahydro-6β,7α-dihydroxy-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione Preparation Products And Raw materials
Tag:(6R)-6,7,8,9-Tetrahydro-6β,7α-dihydroxy-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione(97465-71-9) Related Product Information
2,2-Dimethyl-1,3-propanediol Dihydrotanshinone I 7,8-Dihydro-1,6,6-trimethylphenanthro[1,2-b]furan-9,10,11(6H)-trione Tanshinol B 3alpha-Hydroxytanshinone IIA Hydroxytanshinone IIA