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| | 2-Nitrobenzenesulfonamide Basic information |
| | 2-Nitrobenzenesulfonamide Chemical Properties |
| Melting point | 190-192 °C (lit.) | | Boiling point | 418.8±47.0 °C(Predicted) | | density | 1.505 (estimate) | | refractive index | 1.6490 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO, Methanol (Slightly, Heated, Sonicated) | | form | solid | | pka | 9.24±0.60(Predicted) | | color | Off-White to Brown | | Water Solubility | Slightly soluble in water. | | BRN | 2214215 | | InChI | InChI=1S/C6H6N2O4S/c7-13(11,12)6-4-2-1-3-5(6)8(9)10/h1-4H,(H2,7,11,12) | | InChIKey | GNDKYAWHEKZHPJ-UHFFFAOYSA-N | | SMILES | C1(S(N)(=O)=O)=CC=CC=C1[N+]([O-])=O | | CAS DataBase Reference | 5455-59-4(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Nitrobenzenesulfonamide(5455-59-4) |
| | 2-Nitrobenzenesulfonamide Usage And Synthesis |
| Chemical Properties | yellow to light brown crystalline powder | | Uses | 2-Nitro-benzenesulfonamide is a carbonic anhydrase inhibitor. | | Synthesis | The general procedure for the synthesis of 2-nitrobenzenesulfonamide from o-nitrobenzenesulfonyl chloride was as follows: 120.0 g of 2-nitrobenzenesulfonyl chloride (Compound 1, 0.78 mol) was dissolved in 280 mL of tetrahydrofuran (THF) with 360.0 g of ammonium acetate (4.7 mol), heated to reflux and stirred overnight. After completion of the reaction, the solid product was collected by filtration and processed by vacuum drying to afford 86.0 g of 2-nitrobenzenesulfonamide (compound 2) as a yellow solid in 80% yield. | | References | [1] Journal of Organic Chemistry, 2018, vol. 83, # 16, p. 9088 - 9095
[2] Patent: CN104761514, 2016, B. Location in patent: Paragraph 0023-0025
[3] Patent: JP2005/314398, 2005, A. Location in patent: Page/Page column 25
[4] Justus Liebigs Annalen der Chemie, 1875, vol. 177, p. 62
[5] Magnetic Resonance in Chemistry, 1987, vol. 25, p. 189 - 193 |
| | 2-Nitrobenzenesulfonamide Preparation Products And Raw materials |
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