| Company Name: |
SPIRO PHARMA |
| Tel: |
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| Email: |
eric_feng1954@126.com |
LONAFARNIB manufacturers
- (Rac)-Lonafarnib
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- $2580.00
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2026-05-11
- CAS:193275-86-4
- Purity:
- Supply Ability: 10g
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| | LONAFARNIB Basic information |
| Product Name: | LONAFARNIB | | Synonyms: | Lonafarnib RaceMate;4-[2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide;1-Piperidinecarboxamide, 4-[2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]-;(Rac)-Lonafarnib | | CAS: | 193275-86-4 | | MF: | C27H31Br2ClN4O2 | | MW: | 638.82 | | EINECS: | | | Product Categories: | | | Mol File: | 193275-86-4.mol |  |
| | LONAFARNIB Chemical Properties |
| Boiling point | 710.4±70.0 °C(Predicted) | | density | 1.536±0.06 g/cm3(Predicted) | | pka | 15.76±0.40(Predicted) |
| | LONAFARNIB Usage And Synthesis |
| Uses | (Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities[1]. | | Definition | ChEBI: 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide is a benzocycloheptapyridine that is benzo[5,6]cyclohepta[1,2-b]pyridine which is substituted at positions 3 and 10 by bromines, at position 8 by chlorine, and at position 11 by an N-acetylpiperidin-4-yl group in which one of the hydrogens of the acetyl moiety has been replaced by a 1-carbamoylpiperidin-4-yl group. It is a benzocycloheptapyridine, a N-acylpiperidine, a heteroarylpiperidine, an organochlorine compound, an organobromine compound and a member of ureas. | | References | [1] Liu M, et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res. 1998 Nov 1;58(21):4947-56. PMID:9810004 |
| | LONAFARNIB Preparation Products And Raw materials |
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