| Company Name: |
Adamas Reagent, Ltd.
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| Tel: |
400-6009262 15618770481 |
| Email: |
yhx@titansci.com |
| Products Intro: |
Product Name:2-(Benzyloxy)-4-Bromo-1-Fluorobenzene
CAS:1036724-54-5
Purity:97%+ Package:100mg;250mg;1g;5g;25g;100g
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| Company Name: |
SynAsst Chemical.
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| Tel: |
021-60343070 |
| Email: |
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| Products Intro: |
Product Name:2-(Benzyloxy)-4-broMo-1-fluorobenzene
CAS:1036724-54-5
Purity:96%Min Package:10g 100g 500g
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| | 4-BROMO-1-FLUORO-2-(PHENYLMETHOXY)BENZENE Basic information |
| | 4-BROMO-1-FLUORO-2-(PHENYLMETHOXY)BENZENE Chemical Properties |
| Boiling point | 337.8±27.0 °C(Predicted) | | density | 1.445±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | Appearance | White to off-white Solid |
| | 4-BROMO-1-FLUORO-2-(PHENYLMETHOXY)BENZENE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-(benzyloxy)-4-bromo-1-fluorobenzene from benzyl bromide and 5-bromo-2-fluorophenol: To a solution of acetone (10 ml) containing the product of step a) (0.802 g, 4.20 mmol) and benzyl bromide (0.755 ml, 6.30 mmol) was added potassium carbonate (1.16 g, 8.40 mmol). The mixture was heated at reflux at 60°C for 16 hours. After completion of the reaction, the solid was removed by filtration and washed with acetone. The filtrate was evaporated to give the crude product. The residue was purified by fast chromatography using 0-20% ethyl acetate/isohexane as eluent, resulting in 1.04 g (88% yield) of 2-(benzyloxy)-4-bromo-1-fluorobenzene as an oil, which crystallized on cooling. The NMR hydrogen spectrum (400 MHz, CDCl3) data were as follows: δ 5.08 (2H, s), 6.98 (2H, m), 7.13 (1H, dd, J=7.4,2.2Hz), 7.37 (5H, m). | | References | [1] Patent: WO2004/65388, 2004, A1. Location in patent: Page 47
[2] Patent: US2018/311255, 2018, A1. Location in patent: Paragraph 0204-0205 |
| | 4-BROMO-1-FLUORO-2-(PHENYLMETHOXY)BENZENE Preparation Products And Raw materials |
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