|
|
| | 3-(2,2,2-Trimethylhydrazine)methylpropionate bromide Basic information |
| Product Name: | 3-(2,2,2-Trimethylhydrazine)methylpropionate bromide | | Synonyms: | PROPANOIC ACID, 3-(2,2,2-TRIMETHYLHYDRAZINYL)-, METHYL ESTER BROMIDE;Hydrazinium, 2-(3-methoxy-3-oxopropyl)-1,1,1-trimethyl-, bromide (1:1);Meldonium impurity C CRS;3-(2,2,2-Trimethylhydrazinyl)-propanoic acid methyl ester bromide;2-(3-Methoxy-3-oxopropyl)-1,1,1-trimethylhydrazin-1-ium Bromide;3-(2,2,2-Trimethylhydrazinyl)Methyl Propionate Bromide (Thmp) | | CAS: | 106966-25-0 | | MF: | C7H17N2O2.Br | | MW: | 241.127 | | EINECS: | 463-070-5 | | Product Categories: | | | Mol File: | 106966-25-0.mol |  |
| | 3-(2,2,2-Trimethylhydrazine)methylpropionate bromide Chemical Properties |
| density | 1.38 at 20℃ | | vapor pressure | 5hPa at 20-25℃ | | storage temp. | 2-8°C | | Major Application | pharmaceutical (small molecule) | | InChI | 1S/C7H17N2O2.BrH/c1-9(2,3)8-6-5-7(10)11-4;/h8H,5-6H2,1-4H3;1H/q+1;/p-1 | | InChIKey | XOTJZTAARPYKNA-UHFFFAOYSA-M | | SMILES | [Br-].[N+](NCCC(=O)OC)(C)(C)C | | LogP | -3.26 at 24℃ and pH6.2 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 3-(2,2,2-Trimethylhydrazine)methylpropionate bromide Usage And Synthesis |
| Uses | 3-(2,2,2-Trimethylhydrazine)methylpropionate bromide can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes. | | Synthesis | 
In a three-necked round bottom flask equipped with a mechanical stirrer, a dropping funnel and a reflux condenser, 172 g (2 mol) of methyl acrylate was added, and under cooling, 132 g (2.2 mol) of 1,1-dimethylhydrazine was added dropwise. After a period of 2 hours, the reaction mixture was heated at the same temperature until methyl 3-(2,2-dimethylhydrazo)propionate was formed (monitored by GM-MS). The above methyl 3-(2,2-dimethylhydrazinyl)propanoate product was dissolved in 40% ethanol (350 ml), cooled to 0 ° C, and methyl bromide (189 g, 1.99 mol) was passed for 1 hour, and the temperature was continued. After stirring for 0, 5 hours, the yellow or brown precipitate was filtered off, and the crude product was washed with acetone (1000 ml). The crude 3-(2,2,2-trimethylhydrazine) propionate methyl bromide was dried (265.7 g, yield 91.0%); the crude product was recrystallized from ethanol and dried to give 219.8 g of pale yellow crystalline powder. The rate is 75.3%, the melting point is 130-132°C, and the main content is 103.3%. (The stability is verified by the stability test. The stability is poor, the color gradually becomes deeper. Because the trace impurities contained in the product have a great influence on the product, it is found to have molecular decay and various indicators. Larger, the product is valid for up to two years). |
| | 3-(2,2,2-Trimethylhydrazine)methylpropionate bromide Preparation Products And Raw materials |
|