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SynAsst Chemical.
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Product Name:3-BroMo-2-(hydroxyMethyl)-6-Methoxypyridine
CAS:623942-84-7
Purity:96%Min Package:10g 100g 500g
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| | 3-Bromo-2-(hydroxymethyl)-6-methoxypyridine Basic information |
| | 3-Bromo-2-(hydroxymethyl)-6-methoxypyridine Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | Appearance | Off-white to yellow Solid |
| | 3-Bromo-2-(hydroxymethyl)-6-methoxypyridine Usage And Synthesis |
| Synthesis | Step E. Synthesis of (3-bromo-6-methoxypyridin-2-yl)methanol. A mixture of 3-bromo-6-methoxypyridin-2-ylmethyl acetate (3.94 g, 15.2 mmol) with 1M aqueous potassium carbonate (26.2 mL, 26.2 mmol) in methanol (30 mL) was stirred at room temperature for 18 hours. After completion of the reaction, the mixture was concentrated, diluted with water (15 mL) and extracted with dichloromethane (3 x 15 mL). The organic phases were combined, washed with water, dried over anhydrous sodium sulfate and concentrated to give 3-bromo-2-hydroxymethyl-6-methoxypyridine (2.97 g, 90% yield). Mass spectrum (ESI): calculated value C7H8BrNO2, 216.97; measured value m/z 218.2 [M + H]+. 1H NMR (CDCl3): δ 7.68 (d, J = 8.6 Hz, 1H), 6.60 (d, J = 8.6 Hz, 1H), 4.67 (dd, J = 4.7, 0.6 Hz, 2H), 4.01 (t, J = 4.7 Hz, 1H), 3.97 (s, 3H). | | References | [1] Tetrahedron Letters, 2000, vol. 41, # 12, p. 2007 - 2009
[2] Organic and Biomolecular Chemistry, 2003, vol. 1, # 16, p. 2865 - 2876
[3] Patent: US2006/287292, 2006, A1. Location in patent: Page/Page column 29
[4] Patent: US2016/75711, 2016, A1. Location in patent: Paragraph 0570; 0573 |
| | 3-Bromo-2-(hydroxymethyl)-6-methoxypyridine Preparation Products And Raw materials |
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