PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
| 中文名称 | PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE |
|---|---|
| 中文同义词 | WNT/Β-CATENIN通路抑制剂(PNU-74654);(E)-N'-((-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼;N'-((-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼;PNU 74654,WNT信号通路阻滞剂;N'-((5-甲基呋喃-2-基)亚甲基)-2-苯氧基苯甲酰肼;PNU 74654,WNT SIGNALING PATHWAY BLOCKER;化合物PNU 74654,10 MM DMSO 溶液;PNU-74654 (PNU74654;PNU 74654) |
| 英文名称 | 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide |
| 英文同义词 | 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide;PNU 74654;Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide;PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide;PNU74654; PNU 74654;CS-2563;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;PNU 74654, Wnt signaling pathway blocker |
| CAS号 | 113906-27-7 |
| 分子式 | C19H16N2O3 |
| 分子量 | 320.34 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 113906-27-7.mol |
| 结构式 | ![PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE 结构式](CAS/20181012/GIF/113906-27-7.gif) |
PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE 性质
| 密度 | 1.17±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>10mg/mL |
| 酸度系数(pKa) | 12.12±0.46(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 稳定性 | 自购买之日起 1 年内保持稳定。 DMSO 中的溶液可在 -20° 下保存长达 3 个月。 |
| InChI | 1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+ |
| InChIKey | JJEDWBQZCRESJL-DEDYPNTBSA-N |
| SMILES | Cc1ccc(\C=N\NC(=O)c2ccccc2Oc3ccccc3)o1 |
129.8 μM (Wnt/β-catenin, NCI-H295 cell)
PNU-74654 binds to β-catenin with a K D of 450 nM. The Tcf3/Tcf4-binding surface on β-catenin contains a well-defined hot spot around residues K435 and R469. The binding mode of PNU-74654 involves the two narrow pockets on either side of this hot spot. In NCI-H295 cells,PNU-74654 significantly decreases cell proliferation 96 h after treatment, increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impairs CTNNB1/beta-catenin expression and increases beta-catenin target genes 48 h after treatment. No effects are observed on HeLa cells. In NCI-H295 cells, PNU-74654 decreases cortisol, testosterone and androstenedione secretion 24 and 48 h after treatment. The SF1 and CYP21A2 mRNA expression as well as the protein levels of STAR and aldosterone synthase are decreased in NCI-H295 cells after 48 h PNU-74654 treatment. In Y1 cells, PNU-74654 impairs corticosterone secretion 24 h after treatment but does not decrease cell viability.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-101130 | PNU-74654 | 113906-27-7 | 1 mg | 212元 |
| 2025/12/22 | HY-101130 | PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE PNU-74654 | 113906-27-7 | 5mg | 530元 |