N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide manufacturers
- PD173212
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- $73.00
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2026-07-14
- CAS:217171-01-2
- Purity: 99.84%
- Supply Ability: 10g
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| | N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide Basic information |
| | N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide Chemical Properties |
| Boiling point | 753.4±60.0 °C(Predicted) | | density | 1.053±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | DMSO: 100 mM; Ethanol: 100 mM | | pka | 13.83±0.46(Predicted) | | form | Powder | | color | White to off-white | | InChIKey | GCDHMGROXQUFNR-HEVIKAOCSA-N | | SMILES | O=C([C@@H](NC([C@@H](N(C)CC1=CC=C(C=C1)C(C)(C)C)CC(C)C)=O)CC2=CC=C(OCC3=CC=CC=C3)C=C2)NC(C)(C)C |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide Usage And Synthesis |
| Description | PD 173212 is an N-type calcium channel blocker (IC50 = 36 nM). It prevents audiogenic seizures in mice when administered at a dose of 30 mg/kg. | | Uses | PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays. | | in vivo | PD173212 (30 mg/kg, i.v.) shows moderate efficacy in preventing tonic seizures in the audiogenic seizure model[1]. | | References | [1] Hu LY, et al. Structure-activity relationship of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2151-6. DOI:10.1016/s0960-894x(99)00359-5 |
| | N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide Preparation Products And Raw materials |
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