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| | Methyl 6-bromo-5-fluoropyridine-2-carboxylate Basic information |
| Product Name: | Methyl 6-bromo-5-fluoropyridine-2-carboxylate | | Synonyms: | Methyl 6-bromo-5-fluoropyridine-2-carboxylate;Methyl 6-bromo-5-fluoropicolinate, 2-Bromo-3-fluoro-6-(methoxycarbonyl)pyridine;6-Bromo-5-fluoro-pyridine-2-carboxylic acid methyl ester;methyl 6-bromo-5-fluoropicolinat;6-bromo-5-fL;uoropicoL;2-Pyridinecarboxylic acid, 6-bromo-5-fluoro-, methyl ester;N'-(3,4-dichlorophenyl)ethane-1,6-diamine | | CAS: | 1210419-26-3 | | MF: | C7H5BrFNO2 | | MW: | 234.02 | | EINECS: | | | Product Categories: | | | Mol File: | 1210419-26-3.mol |  |
| | Methyl 6-bromo-5-fluoropyridine-2-carboxylate Chemical Properties |
| Boiling point | 275.5±35.0 °C(Predicted) | | density | 1.660±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | -3.45±0.10(Predicted) | | form | solid | | color | white |
| | Methyl 6-bromo-5-fluoropyridine-2-carboxylate Usage And Synthesis |
| Synthesis | Synthesis of methyl 6-bromo-5-fluoro-pyridinecarboxylate: Concentrated sulfuric acid (4.2 eq.) was slowly added to a methanol (0.2 M) solution of 6-bromo-5-fluoro-2-pyridinecarboxylic acid (1.0 eq.) and the reaction mixture was stirred at room temperature. The progress of the reaction was monitored by LC/MS and the reaction was completed after about 2 hours. The reaction mixture was diluted with ethyl acetate and saturated aqueous sodium bicarbonate solution was added slowly to quench the reaction. The mixture was transferred to a partition funnel and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford methyl 6-bromo-5-fluoropyridinecarboxylate as a white solid (yield >99%). The product was characterized by LC/MS: m/z = 233.9/235.9 ([M+H]+), retention time Rt = 0.69 min. | | References | [1] Patent: US2010/56576, 2010, A1. Location in patent: Page/Page column 48
[2] Patent: WO2012/4217, 2012, A1. Location in patent: Page/Page column 65-66
[3] Patent: US2012/225062, 2012, A1. Location in patent: Page/Page column 26; 27
[4] Patent: US2012/225061, 2012, A1. Location in patent: Page/Page column 22
[5] Patent: WO2013/175388, 2013, A1. Location in patent: Page/Page column 44 |
| | Methyl 6-bromo-5-fluoropyridine-2-carboxylate Preparation Products And Raw materials |
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