- Trichostatin A
-
- $86.00 / 1mg
-
2026-03-13
- CAS:58880-19-6
- Min. Order:
- Purity: 98.59%
- Supply Ability: 10g
- Trichostatin A
-
- $10.00 / 1kg
-
2024-04-02
- CAS:58880-19-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000 Metric Ton/Month
- trichostatin A
-
- $0.00 / 1KG
-
2021-03-17
- CAS:58880-19-6
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 1 ton
|
| Product Name: | TRICHOSTATIN A | | Synonyms: | 7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide;7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID;Trichostatin A from Streptomyces platensis;[r-(e,e)]-7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide;7-(4-DIMETHYLAMINOPHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-HEPTA-2,4-DIENAMIDE;TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide | | CAS: | 58880-19-6 | | MF: | C17H22N2O3 | | MW: | 302.37 | | EINECS: | 611-758-2 | | Product Categories: | Inhibitors;antibiotic;API;Anti Cancer Research;Inhibitor | | Mol File: | 58880-19-6.mol |  |
| | TRICHOSTATIN A Chemical Properties |
| Melting point | 140-143℃ | | alpha | D20.5 +62.8° ±1.1° (c = 1.007 in ethanol) | | density | 1.139 | | refractive index | 136 ° (C=0.3, MeOH) | | storage temp. | -20°C | | solubility | ethanol: 1 mg/mL | | pka | 8.93±0.23(Predicted) | | form | Off-white lyophilized solid | | color | Tan | | biological source | Streptomyces sp. | | Merck | 14,9649 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | InChI | 1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 | | InChIKey | ZWGICMNKJBUOHG-RCXLNATQSA-N | | SMILES | C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C |
| Hazard Codes | Xn,Xi | | Risk Statements | 20/21/22-36/37/38-43 | | Safety Statements | 26-36 | | RIDADR | NA 1993 / PGIII | | WGK Germany | 3 | | RTECS | MI5215000 | | HS Code | 29280000 | | Storage Class | 11 - Combustible Solids |
| | TRICHOSTATIN A Usage And Synthesis |
| Description | Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo. | | Chemical Properties | Solid | | Uses | Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells. | | Uses | Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity | | Uses | Trichostatin A, ready-made solution has been used:
- as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
- to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
- to treat cells for the HDAC inhibition experiments
| | Definition | ChEBI: Trichostatin A is an antibiotic antifungal agent, a trichostatin and a hydroxamic acid. It has a role as a bacterial metabolite, a geroprotector and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is functionally related to a (R)-trichostatic acid. | | General Description | Trichostatin A is a compound of primary hydroxamic acid. | | Biological Activity | Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. | | Biochem/physiol Actions | Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA. | | storage | -20°C (desiccate) | | Background | Trichostatin A is an antifungal antibiotic derived from Streptomyces that inhibits mammalian histone deacetylases. When used at nanomolar concentrations, trichostatin A causes the accumulation of acetylated histones in a quite specific and reversible manner. Trichostatin A has also been shown to inhibit both G1- and G2-phases of the mammalian cell cycle and has been tested for use as a potential anticancer agent. | | References | [1] M YOSHIDA. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.[J]. The Journal of Biological Chemistry, 1990, 265 28: 17174-17179.
[2] M FUTAMURA. Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells.[J]. Oncogene, 1995, 10 6: 1119-1123.
[3] GABRIELA DURCOVA-HILLS. Reprogramming primordial germ cells into pluripotent stem cells.[J]. PLoS ONE, 2008, 3 10: e3531. DOI:10.1371/journal.pone.0003531 |
| | TRICHOSTATIN A Preparation Products And Raw materials |
|