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Product Name:GW 848687X
CAS:612831-24-0
Purity:98% Package:1G;10G;100G Remarks:GW 848687X is a potent and selective antagonist of EP1 receptor (IC50 = 2.5 nM). GW 848687X displays >400-fold selectivity for EP1 relative to the other EP receptor subtypes, the PGD2 receptor, DP1, a
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Shanghai Hongye Biotechnology Co. Ltd
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Product Name:GW 848687X
CAS:612831-24-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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Product Name:GW 848687X
CAS:612831-24-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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MedBioPharmaceutical Technology Inc
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| Products Intro: |
Product Name:GW 848687X
CAS:612831-24-0
Purity:98% Package:5mg (solution); 1mg (solution); 500ug (solution) Remarks:Medbio
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GW 848687X manufacturers
- GW848687X
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- $1750.00 / 5mg
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2024-10-24
- CAS:612831-24-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | GW 848687X Basic information |
| Product Name: | GW 848687X | | Synonyms: | GW 848687X;PFODPHDNBFSMOX-UHFFFAOYSA-N;2-Pyridinecarboxylic acid, 6-[2-[5-chloro-2-[(2,4-difluorophenyl)methoxy]phenyl]-1-cyclopenten-1-yl]- | | CAS: | 612831-24-0 | | MF: | C24H18ClF2NO3 | | MW: | 441.85 | | EINECS: | | | Product Categories: | | | Mol File: | 612831-24-0.mol |  |
| | GW 848687X Chemical Properties |
| Boiling point | 622.8±55.0 °C(Predicted) | | density | 1.393±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 5 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml | | pka | 1.09±0.50(Predicted) |
| | GW 848687X Usage And Synthesis |
| Uses | GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain[1]. | | in vivo | GW 848687X (30 mg/kg; po; b.i.d, 5 d) exhibits antihyperalgesic activity in an FCA-induced inflammatory joint pain model[1].
| Animal Model: | FCA induced joint pain model of inflammatory pain[1] | | Dosage: | 30mg/kg | | Administration: | po; twice daily for 5 days | | Result: | Completely reversed pain sensation in rats and had anti-pain effects. |
| | References | [1] Giblin GM, et al. The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett. 2007 Jan 15;17(2):385-9. DOI:10.1016/j.bmcl.2006.10.041 |
| | GW 848687X Preparation Products And Raw materials |
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