JWH 200 5-hydroxyindole metabolite

Request For Quotation
JWH 200 5-hydroxyindole metabolite Suppliers list
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
JWH 200 5-hydroxyindole metabolite Basic information
Product Name:JWH 200 5-hydroxyindole metabolite
Synonyms:JWH 200 5-hydroxyindole metabolite;[5-hydroxy-1-(2-morpholin-4-ylethyl)indol-3-yl]-naphthalen-1-ylmethanone;Methanone, [5-hydroxy-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-1-naphthalenyl-
CAS:133438-72-9
MF:C25H24N2O3
MW:400.47
EINECS:
Product Categories:
Mol File:133438-72-9.mol
JWH 200 5-hydroxyindole metabolite Structure
JWH 200 5-hydroxyindole metabolite Chemical Properties
Boiling point 648.3±55.0 °C(Predicted)
density 1.27±0.1 g/cm3(Predicted)
solubility DMF: 5 mg/ml; DMSO: 3 mg/ml; Ethanol: 5 mg/ml
form A crystalline solid
pka9.39±0.40(Predicted)
Safety Information
MSDS Information
JWH 200 5-hydroxyindole metabolite Usage And Synthesis
DescriptionJWH 200 is an aminoalkylindole that acts as a cannabinoid (CB) receptor agonist, binding the CB1 receptor with high-affinity (IC50 = 7.8-42 nM).1,2 It is one of several synthetic CBs which have been included in smoking mixtures. JWH 200 5-hydroxyindole metabolite is expected to be a urinary metabolite of JWH 200 based on the metabolism of the closely-related JWH 015 and JWH 018.3,4
References1. Eissenstat, M.A., Bell, M.R., D'Ambra, T.E., et al. Aminoalkylindoles: Structure-activity relationships of novel cannabinoid mimetics J. Med. Chem. 38,3094-3105(1995).
2. Huffman, J.W., Mabon, R., Wu, M.J., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor Bioorgan. Med. Chem. 11(4),539-549(2003).
3. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS Anal. Bioanal. Chem. 386(5),1345-1355(2006).
4. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine Forensic Sci. Int. 200(1-3),141-147(2010).
JWH 200 5-hydroxyindole metabolite Preparation Products And Raw materials
Tag:JWH 200 5-hydroxyindole metabolite(133438-72-9) Related Product Information
JWH 200 6-hydroxyindole metabolite (4-ethylnaphthalen-1-yl)-(5-hydroxy-1-pentylindol-3-yl)methanone JWH 200 7-hydroxyindole metabolite JWH 200 4-hydroxyindole metabolite JWH 073 2-hydroxyindole metabolite