| Company Name: |
Cochemical Ltd. |
| Tel: |
029-86115547 17791676824 |
| Email: |
sales@cochemical.com |
2,4-difluoro-5-nitropyridine manufacturers
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| | 2,4-difluoro-5-nitropyridine Basic information |
| | 2,4-difluoro-5-nitropyridine Chemical Properties |
| Melting point | 42 °C | | Boiling point | 246.0±35.0 °C(Predicted) | | density | 1.555±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -5.60±0.18(Predicted) | | Appearance | Off-white to light yellow Solid |
| | 2,4-difluoro-5-nitropyridine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2,4-difluoro-5-nitropyridine from 2,4-dichloro-5-nitropyridine: In a 250 mL round-bottomed flask, 2,4-dichloro-5-nitropyridine (0.73 g, 3.8 mmol), potassium fluoride (0.659 g, 11.3 mmol) and 18-crown-6 (0.160 g, 0.605 mmol) were added to an N-methyl pyrrolidone (3 mL) solution to form a brown suspension. The reaction mixture was heated to reflux at 100 °C under nitrogen atmosphere for 3 hours. Upon completion of the reaction, the mixture was partitioned between water and a mixed ether/hexane solvent. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the brown solid product 2,4-difluoro-5-nitropyridine (0.515 g, 85% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) δ 9.07 (d, J = 9.7 Hz, 1H), 6.96 (dd, J = 9.5, 2.5 Hz, 1H) and 19F NMR (376 MHz, CDCl3) δ -52.20 (d, J = 29.3 Hz), -98.13 (d, J = 28.9 Hz). | | References | [1] Patent: WO2015/69594, 2015, A1. Location in patent: Page/Page column 106
[2] Patent: WO2018/98413, 2018, A1. Location in patent: Page/Page column 16
[3] Patent: WO2018/98411, 2018, A1. Location in patent: Page/Page column 94; 95 |
| | 2,4-difluoro-5-nitropyridine Preparation Products And Raw materials |
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