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| | 1H-Indole-2-carboxylic acid, 4-Methyl-, ethyl ester Basic information |
| | 1H-Indole-2-carboxylic acid, 4-Methyl-, ethyl ester Chemical Properties |
| Melting point | 140-141 °C | | Boiling point | 355.6±22.0 °C(Predicted) | | density | 1.177±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 15.37±0.30(Predicted) | | Appearance | White to light yellow Solid | | InChI | InChI=1S/C12H13NO2/c1-3-15-12(14)11-7-9-8(2)5-4-6-10(9)13-11/h4-7,13H,3H2,1-2H3 | | InChIKey | ZUJVXCIAKURESZ-UHFFFAOYSA-N | | SMILES | N1C2=C(C(C)=CC=C2)C=C1C(OCC)=O |
| | 1H-Indole-2-carboxylic acid, 4-Methyl-, ethyl ester Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of ethyl 4-methyl-1hydro-indole-2-carboxylate from the compound (CAS: 24512-97-8) was as follows: 19.5 g (0.0844 mol) of the azide prepared in step 1 was added in batches to 100 mL of xylene preheated to 140 °C. After the addition was completed, the reaction mixture was kept at 140 °C for 1 hour. At the end of the reaction, the xylene was removed by concentration via reduced pressure distillation, and the residue was dissolved in isopropyl ether, filtered, and dried under vacuum at 40 °C for 18 h to give a white crystalline product. The melting point of the product was 141 °C and the yield was 62%. | | References | [1] Journal of the Chemical Society, Chemical Communications, 1982, # 1, p. 3 - 4
[2] Patent: US2004/43995, 2004, A1. Location in patent: Page 13 |
| | 1H-Indole-2-carboxylic acid, 4-Methyl-, ethyl ester Preparation Products And Raw materials |
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